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Details on Person UniProt:P15409 Rho
| Class:Id | ReferenceGeneProduct:74484 |
|---|---|
| _chainChangeLog | chain:1-348 added on Fri February 6 2015 |
| _displayName | UniProt:P15409 Rho |
| _timestamp | 2024-08-09 19:14:34 |
| chain | chain:1-348 |
| checksum | B336C04B699AFF75 |
| comment | FUNCTION Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (PubMed:9020854). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (PubMed:27353443).SUBUNIT Homodimer (By similarity). May form a complex composed of RHO, GRK1 and RCVRN in a Ca(2+)-dependent manner; RCVRN prevents the interaction between GRK1 and RHO (By similarity). Interacts with GRK1 (By similarity). Interacts (phosphorylated form) with SAG (By similarity). Interacts with GNAT1 (By similarity). Interacts with GNAT3. SAG and G-proteins compete for a common binding site (By similarity). Interacts with PRCD; the interaction promotes PRCD stability (PubMed:27509380). Forms a complex with ASAP1 and ARF4. Forms a complex with ASAP1, RAB11A, Rabin8/RAB3IP, ARF4 and RAB11FIP3; the complex regulates Golgi-to-cilia rhodopsin/RHO transport in photoreceptors (By similarity).SUBCELLULAR LOCATION Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia.TISSUE SPECIFICITY Rod-shaped photoreceptor cells in the retina (at protein level).DEVELOPMENTAL STAGE Expressed in the outer segment of retinal photoreceptors at postnatal days 11 and 22.PTM Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.PTM Contains one covalently linked retinal chromophore. Upon light absorption, the covalently bound 11-cis-retinal is converted to all-trans-retinal. After hydrolysis of the Schiff base and release of the covalently bound all-trans-retinal, active rhodopsin is regenerated by binding of a fresh molecule of 11-cis-retinal.DISRUPTION PHENOTYPE Mice show no response in electroretinograms at low light intensity (PubMed:9020854). They fail to form rod outer segments leading to degeneration of photoreceptor cells within 3 months of birth (PubMed:32312889, PubMed:9020854).SIMILARITY Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. |
| description | recommendedName: Rhodopsin |
| geneName | Rho |
| identifier | P15409 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Cell projection Chromophore Disulfide bond G-protein coupled receptor Glycoprotein Lipoprotein Membrane Metal-binding Palmitate Phosphoprotein Photoreceptor protein Receptor Reference proteome Retinal protein Sensory transduction Transducer Transmembrane Transmembrane helix Vision Zinc |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9666080] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 |
| name | Rho |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | OPSD_MOUSE Q8K0D8 Q96DZ2 |
| sequenceLength | 348 |
| species | [Species:48892] Mus musculus |
| (referenceSequence) | [ModifiedResidue:74485] O-phospho-L-serine at unknown position [ModifiedResidue:74486] O-phospho-L-threonine at unknown position |
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No pathways have been reviewed or authored by UniProt:P15409 Rho (74484)
