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Details on Person (deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)

Class:IdReaction:74376
_displayName(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)
_doReleaseTRUE
_timestamp2025-12-11 22:35:48
catalystActivity[CatalystActivity:73557] uridine phosphorylase activity of UPP1, UPP2 [cytosol]
catalystActivityReference[CatalystActivityReference:9643140] uridine phosphorylase activity of UPP1, UPP2 [cytosol] Cloning and expression of human uridine phosphorylase
compartment[Compartment:70101] cytosol
created[InstanceEdit:74362] D'Eustachio, P, 2003-07-18 15:39:00
crossReference[DatabaseIdentifier:9976507] RHEA:24389
[DatabaseIdentifier:9976526] RHEA:22825
input[DefinedSet:500430] (d)Ura [cytosol]
[SimpleEntity:29372] Pi [cytosol]
literatureReference[LiteratureReference:112252] Cloning and expression of human uridine phosphorylase
[LiteratureReference:500431] Implications of the structure of human uridine phosphorylase 1 on the development of novel inhibitors for improving the therapeutic window of fluoropyrimidine chemotherapy
[LiteratureReference:977407] Identification of a novel human uridine phosphorylase
modified[InstanceEdit:112212] D'Eustachio, P, 2004-04-15 11:50:00
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:500432] D'Eustachio, P, 2010-02-03
[InstanceEdit:500840] D'Eustachio, P, 2010-02-05
[InstanceEdit:504063] D'Eustachio, P, 2010-02-05
[InstanceEdit:504071] D'Eustachio, P, 2010-02-07
[InstanceEdit:977409] Jassal, B, 2010-10-19
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:8956390] D'Eustachio, Peter, 2017-01-22
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9976516] D'Eustachio, Peter, 2025-12-11
name(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)
uridine + phosphate => alpha-D-ribose 1-phosphate + uracil
2'-deoxyuridine + phosphate => 2-deoxy-alpha-D-ribose 1-phosphate + uracil
output[SimpleEntity:83962] Ura [cytosol]
[DefinedSet:500244] R1P, dRibP [cytosol]
precedingEvent
releaseDate2004-07-06
reverseReaction
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:361395] R-HSA-74376.6
summation[Summation:178311] Cytosolic uridine phosphorylase (isoforms UPP1 and UPP2) cat...
(hasEvent)[Pathway:73621] Pyrimidine catabolism [Homo sapiens]
(replacementInstances)[_Deleted:500435] Deletion of instance: 73560
(reverseReaction)[Reaction:74372] uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] [Homo sapiens]
(updatedInstance)[_UpdateTracker:9790042] Update Tracker - [Reaction:74376] (deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) - v35:[addLiteratureReference, modifyText]
[_UpdateTracker:9790894] Update Tracker - [Reaction:74376] (deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) - v32:[add_removeInput, add_removeLiteratureReference, add_removeOutput, modifyText]
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No pathways have been reviewed or authored by (deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (74376)
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