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Details on Person Once the TNF-α:TNFR1:TRADD:RIPK1 complex has been formed the...
| Class:Id | Summation:74302 |
|---|---|
| _displayName | Once the TNF-α:TNFR1:TRADD:RIPK1 complex has been formed the... |
| _timestamp | 2022-06-30 05:18:14 |
| literatureReference | [LiteratureReference:140979] Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes [LiteratureReference:5357891] Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation |
| modified | [InstanceEdit:110070] Joshi-Tope, G, 2004-01-28 14:40:07 [InstanceEdit:140952] Gillespie, ME, 2004-08-24 21:33:15 [InstanceEdit:140985] Gillespie, ME, 2004-08-25 17:33:06 [InstanceEdit:141957] Matthews, L, 2004-10-05 14:00:00 [InstanceEdit:5660779] Shamovsky, V, 2015-01-06 [InstanceEdit:5692383] Shamovsky, Veronica, 2015-05-12 [InstanceEdit:6793332] Shamovsky, Veronica, 2015-09-01 [InstanceEdit:9794240] Shamovsky, Veronica, 2022-06-30 |
| text | Once the TNF-α:TNFR1:TRADD:RIPK1 complex has been formed there is concomitant recruitment of TRAF2, BIRC2/3 (cIAP1/2) and then of the TAB2:TAK1 and the IKK complex. TRAF2 and BIRC (cIAP1) were found to form a complex in solution (Zheng C et al. 2010), suggesting that TNFR1:TRADD:RIPK1 receptor complex recruits the TRAF2:BIRC complex as a whole. However, the expression levels of BIRCs are typically lower compared to TRAF2 suggesting that TNF-stimulated TNFR1 complex may also recruit TRAF2 alone. RIPK1 and the TRAF2:cIAP1/2 can be released from TNFR1 receptor complex in a poorly understood process associated with internalization and after that there is the formation of a so called complex II containing the adapter protein FADD, caspase-8 and RIPK1. Complex II has the potential to activate caspase-8 (Micheau O & Tschopp J 2003). The steps leading to the JUN, NF kappaB or apoptotic pathways are rife with opportunities for modulation. |
| (summation) | [Reaction:83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 [Homo sapiens] [Reaction:5334740] HPV Suppressed TNF:TNF-R1 binds TRADD, TRAF2 and RIP [Homo sapiens] |
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No pathways have been reviewed or authored by Once the TNF-α:TNFR1:TRADD:RIPK1 complex has been formed the... (74302)
