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Details on Person XDH oxidizes xanthine to form urate

Class:Id	Reaction:74258
_displayName	XDH oxidizes xanthine to form urate
_doRelease	TRUE
_timestamp	2025-12-10 22:50:02
authored	[InstanceEdit:74183] Jassal, B, 2003-07-17 08:31:43
catalystActivity	[CatalystActivity:74246] xanthine oxidase activity of XDH dimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9727337] xanthine oxidase activity of XDH dimer [cytosol] Mutations associated with functional disorder of xanthine oxidoreductase and hereditary xanthinuria in humans
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:74183] Jassal, B, 2003-07-17 08:31:43
crossReference	[DatabaseIdentifier:9976329] RHEA:21133
edited	[InstanceEdit:74183] Jassal, B, 2003-07-17 08:31:43
input	[SimpleEntity:30064] XAN [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29368] O2 [cytosol]
literatureReference	[LiteratureReference:9727338] Mutations associated with functional disorder of xanthine oxidoreductase and hereditary xanthinuria in humans [LiteratureReference:200234] Cloning and expression in vitro of human xanthine dehydrogenase/oxidase [LiteratureReference:500147] Human xanthine oxidase changes its substrate specificity to aldehyde oxidase type upon mutation of amino acid residues in the active site: roles of active site residues in binding and activation of purine substrate
modified	[InstanceEdit:76021] D'Eustachio, P, 2003-09-15 12:36:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:200252] D'Eustachio, P, 2007-07-16 20:10:20 [InstanceEdit:500141] D'Eustachio, P, 2010-01-31 [InstanceEdit:504063] D'Eustachio, P, 2010-02-05 [InstanceEdit:504071] D'Eustachio, P, 2010-02-07 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9727339] D'Eustachio, Peter, 2021-04-15 [InstanceEdit:9731153] D'Eustachio, Peter, 2021-05-13 [InstanceEdit:9731186] D'Eustachio, Peter, 2021-05-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9976335] D'Eustachio, Peter, 2025-12-10
name	XDH oxidizes xanthine to form urate xanthine + O2 + H2O => urate + H2O2
output	[SimpleEntity:30034] urate [cytosol] [SimpleEntity:29408] H2O2 [cytosol]
precedingEvent	[Reaction:74255] Guanine + H2O => Xanthine + NH4+ [Homo sapiens] [Reaction:74249] PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose [Homo sapiens] [Reaction:8953339] DNPH1 hydrolyses dGMP [Homo sapiens] [FailedReaction:9734274] Defective HPRT1 does not convert guanine or hypoxanthine to GMP or IMP [Homo sapiens] [Reaction:74247] XDH oxidizes hypoxanthine to form xanthine [Homo sapiens] [Reaction:74242] PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose [Homo sapiens] [FailedReaction:9734274] Defective HPRT1 does not convert guanine or hypoxanthine to GMP or IMP [Homo sapiens]
releaseDate	2004-07-06
reviewed	[InstanceEdit:9731185] Jassal, Bijay, 2021-05-14
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05 [InstanceEdit:9727345] D'Eustachio, Peter, 2021-04-15
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359194] R-HSA-74258.6
summation	[Summation:179337] Cytosolic xanthine dehydrogenase (XDH) in its oxidase form c...
(hasEvent)	[Pathway:74259] Purine catabolism [Homo sapiens]
(precedingEvent)	[Reaction:71676] GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O [Homo sapiens] [Reaction:76031] 2 H2O2 => O2 + 2 H2O [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776215] Update Tracker - [Reaction:74258] XDH oxidizes xanthine to form urate - v77:[addLiteratureReference, modifyText] [_UpdateTracker:9791032] Update Tracker - [Reaction:74258] XDH oxidizes xanthine to form urate - v32:[addLiteratureReference, modifyText] [_UpdateTracker:9792333] Update Tracker - [Reaction:74258] XDH oxidizes xanthine to form urate - v22:[addLiteratureReference]
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