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Details on Person Guanine + H2O => Xanthine + NH4+

Class:Id	Reaction:74255
_displayName	Guanine + H2O => Xanthine + NH4+
_doRelease	TRUE
_timestamp	2025-12-10 22:49:46
catalystActivity	[CatalystActivity:74254] guanine deaminase activity of GDA dimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643099] guanine deaminase activity of GDA dimer [cytosol] Cloning and characterization of human guanine deaminase. Purification and partial amino acid sequence of the mouse protein.
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:74183] Jassal, B, 2003-07-17 08:31:43
crossReference	[DatabaseIdentifier:9976359] RHEA:14666
input	[SimpleEntity:83956] Gua [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:70106] H+ [cytosol]
literatureReference	[LiteratureReference:200117] Cloning and characterization of human guanine deaminase. Purification and partial amino acid sequence of the mouse protein. [LiteratureReference:500137] Alteration of enzyme specificity by computational loop remodeling and design
modified	[InstanceEdit:76541] D'Eustachio, P, 2003-10-09 12:23:00 [InstanceEdit:76579] D'Eustachio, P, 2003-10-11 14:30:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:200032] D'Eustachio, P, 2007-07-13 20:48:01 [InstanceEdit:500141] D'Eustachio, P, 2010-01-31 [InstanceEdit:500253] D'Eustachio, P, 2010-02-01 [InstanceEdit:504063] D'Eustachio, P, 2010-02-05 [InstanceEdit:504071] D'Eustachio, P, 2010-02-07 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8954161] Jassal, Bijay, 2017-01-05 [InstanceEdit:8956350] D'Eustachio, Peter, 2017-01-21 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9737588] D'Eustachio, Peter, 2021-07-20 [InstanceEdit:9758278] D'Eustachio, Peter, 2021-11-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9976335] D'Eustachio, Peter, 2025-12-10
name	Guanine + H2O => Xanthine + NH4+ guanine + H2O + H(+) => xanthine + NH4(+)
output	[SimpleEntity:30064] XAN [cytosol] [SimpleEntity:31633] NH4+ [cytosol]
precedingEvent	[Reaction:74249] PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose [Homo sapiens] [Reaction:74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) [Homo sapiens] [Reaction:8953339] DNPH1 hydrolyses dGMP [Homo sapiens] [FailedReaction:9734274] Defective HPRT1 does not convert guanine or hypoxanthine to GMP or IMP [Homo sapiens] [Reaction:74242] PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose [Homo sapiens] [Reaction:74249] PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359399] R-HSA-74255.8
summation	[Summation:178834] Cytosolic guanine deaminase (GDA) catalyzes the reaction of ...
(hasEvent)	[Pathway:74259] Purine catabolism [Homo sapiens]
(precedingEvent)	[Reaction:74258] XDH oxidizes xanthine to form urate [Homo sapiens] [Reaction:9727349] XDH dehydrogenates xanthine to form urate [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775912] Update Tracker - [Reaction:74255] Guanine + H2O => Xanthine + NH4+ - v78:[addInput] [_UpdateTracker:9781613] Update Tracker - [Reaction:74255] Guanine + H2O => Xanthine + NH4+ - v60:[add_removeOutput] [_UpdateTracker:9791142] Update Tracker - [Reaction:74255] Guanine + H2O => Xanthine + NH4+ - v32:[addLiteratureReference, modifyText] [_UpdateTracker:9792381] Update Tracker - [Reaction:74255] Guanine + H2O => Xanthine + NH4+ - v22:[addLiteratureReference]
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