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Details on Person PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose

Class:Id	Reaction:74249
_displayName	PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose
_doRelease	TRUE
_timestamp	2025-12-10 22:49:58
catalystActivity	[CatalystActivity:74238] purine-nucleoside phosphorylase activity of PNP trimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643298] purine-nucleoside phosphorylase activity of NP trimer [cytosol] Characterization of purine nucleoside phosphorylase from human granulocytes and its metabolism of deoxyribonucleosides
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:74183] Jassal, B, 2003-07-17 08:31:43
crossReference	[DatabaseIdentifier:9976358] RHEA:13234 [DatabaseIdentifier:9976348] RHEA:27739
input	[SimpleEntity:29372] Pi [cytosol] [DefinedSet:500245] G, dG [cytosol]
literatureReference	[LiteratureReference:112023] Characterization of purine nucleoside phosphorylase from human granulocytes and its metabolism of deoxyribonucleosides [LiteratureReference:112027] A human purine nucleoside phosphorylase deficiency caused by a single base change [LiteratureReference:112018] Three-dimensional structure of human erythrocytic purine nucleoside phosphorylase at 3.2 A resolution
modified	[InstanceEdit:76541] D'Eustachio, P, 2003-10-09 12:23:00 [InstanceEdit:76579] D'Eustachio, P, 2003-10-11 14:30:00 [InstanceEdit:76607] D'Eustachio, P, 2003-10-11 16:03:00 [InstanceEdit:112010] D'Eustachio, P, 2004-03-31 17:07:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:500249] D'Eustachio, P, 2010-02-01 [InstanceEdit:500257] D'Eustachio, P, 2010-02-01 [InstanceEdit:504063] D'Eustachio, P, 2010-02-05 [InstanceEdit:504071] D'Eustachio, P, 2010-02-07 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8956390] D'Eustachio, Peter, 2017-01-22 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9735771] D'Eustachio, Peter, 2021-07-02 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9976335] D'Eustachio, Peter, 2025-12-10
name	PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose guanosine + phosphate => alpha-D-ribose 1-phosphate + guanine 2'-deoxyguanosine + phosphate => 2-deoxy-alpha-D-ribose 1-phosphate + guanine
output	[SimpleEntity:83956] Gua [cytosol] [DefinedSet:500244] R1P, dRibP [cytosol]
precedingEvent	[Reaction:74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) [Homo sapiens] [Reaction:73797] FAICAR => IMP + H2O [Homo sapiens] [Reaction:74215] HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP [Homo sapiens] [Reaction:76590] AMP + H2O => IMP + NH4+ (AMPD) [Homo sapiens] [Reaction:73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate [Homo sapiens]
releaseDate	2004-07-06
reverseReaction	[Reaction:112034] PNP catalyzes the conversion of guanine and (deoxy)ribose-1-phosphate to (deoxy)guanosine [Homo sapiens] [Reaction:74249] PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose [Homo sapiens]
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361480] R-HSA-74249.7
summation	[Summation:178292] Cytosolic purine nucleoside phosphorylase (PNP) trimer catal...
(hasEvent)	[Pathway:74259] Purine catabolism [Homo sapiens]
(normalReaction)	[FailedReaction:9735789] Defective PNP does not convert (deoxy)guanosine to guanine and (deoxy)ribose [Homo sapiens]
(precedingEvent)	[Reaction:74255] Guanine + H2O => Xanthine + NH4+ [Homo sapiens] [FailedReaction:9734274] Defective HPRT1 does not convert guanine or hypoxanthine to GMP or IMP [Homo sapiens]
(replacementInstances)	[_Deleted:500250] Deletion of instance: 74251 [_Deleted:500251] Deletion of instance: 112017
(reverseReaction)	[Reaction:112034] PNP catalyzes the conversion of guanine and (deoxy)ribose-1-phosphate to (deoxy)guanosine [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775320] Update Tracker - [Reaction:74249] PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose - v79:[modifyText] [_UpdateTracker:9775608] Update Tracker - [Reaction:74249] PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose - v78:[modifyText] [_UpdateTracker:9790974] Update Tracker - [Reaction:74249] PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose - v32:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
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