Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)

Class:Id	Reaction:74248
_displayName	(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)
_doRelease	TRUE
_timestamp	2025-12-10 22:49:42
catalystActivity	[CatalystActivity:109324] 5'-nucleotidase activity of NT5C2 tetramer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643271] 5'-nucleotidase activity of NT5C2 tetramer [cytosol] Crystal structure of human cytosolic 5'-nucleotidase II: insights into allosteric regulation and substrate recognition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:74183] Jassal, B, 2003-07-17 08:31:43
crossReference	[DatabaseIdentifier:9976355] RHEA:27715 [DatabaseIdentifier:9976336] RHEA:29380 [DatabaseIdentifier:9976361] RHEA:27719 [DatabaseIdentifier:9976350] RHEA:29384
input	[DefinedSet:500120] (d)GMP, (d)IMP [cytosol] [SimpleEntity:29356] H2O [cytosol]
literatureReference	[LiteratureReference:109314] High Km soluble 5'-nucleotidase from human placenta [LiteratureReference:500117] Crystal structure of human cytosolic 5'-nucleotidase II: insights into allosteric regulation and substrate recognition [LiteratureReference:109348] Cytosolic high Km 5'-nucleotidase and 5'(3')-deoxyribonucleotidase in substrate cycles involved in nucleotide metabolism [LiteratureReference:109319] Distinct roles for recombinant cytosolic 5'-nucleotidase I and -II in AMP and IMP catabolism in COS-7 and H9c2 rat myoblast cell lines [LiteratureReference:109306] Mammalian 5'-nucleotidases
modified	[InstanceEdit:76579] D'Eustachio, P, 2003-10-11 14:30:00 [InstanceEdit:109313] D'Eustachio, P, 2003-12-30 17:15:00 [InstanceEdit:109559] D'Eustachio, P, 2004-01-14 14:55:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:500111] D'Eustachio, P, 2010-01-31 [InstanceEdit:504063] D'Eustachio, P, 2010-02-05 [InstanceEdit:504071] D'Eustachio, P, 2010-02-07 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8956390] D'Eustachio, Peter, 2017-01-22 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9976335] D'Eustachio, Peter, 2025-12-10
name	(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) GMP + H2O => guanosine + phosphate dGMP + H2O => 2'-deoxyguanosine + phosphate IMP + H2O => inosine + phosphate dIMP + H2O => 2'-deoxyinosine + phosphate
output	[DefinedSet:500118] Gu-Rib, dG, Ino, dI [cytosol] [SimpleEntity:29372] Pi [cytosol]
precedingEvent	[Reaction:73797] FAICAR => IMP + H2O [Homo sapiens] [Reaction:73798] AICAR + 10-Formyl-THF => FAICAR + THF [Homo sapiens] [Reaction:74215] HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP [Homo sapiens] [Reaction:76590] AMP + H2O => IMP + NH4+ (AMPD) [Homo sapiens] [Reaction:74213] APRT catalyzes the conversion of adenine to AMP [Homo sapiens] [Reaction:73828] adenylosuccinate => adenosine 5'-monophosphate + fumarate [Homo sapiens] [Reaction:73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate [Homo sapiens] [Reaction:73794] IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360566] R-HSA-74248.6
summation	[Summation:178300] Cytosolic purine 5'-nucleotidase (NT5C2) catalyzes the hydro...
(hasEvent)	[Pathway:74259] Purine catabolism [Homo sapiens]
(inferredFrom)	[Reaction:421179] inosine 5'-monophosphate (IMP) + H2O => inosine + orthophosphate [Gallus gallus]
(precedingEvent)	[Reaction:74249] PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose [Homo sapiens]
(replacementInstances)	[_Deleted:500122] Deletion of instances: 109332, 109325, 74250, 73822
(updatedInstance)	[_UpdateTracker:9787381] Update Tracker - [Reaction:74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) - v45:[modifyText] [_UpdateTracker:9790830] Update Tracker - [Reaction:74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) - v32:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
[Change default viewing format]

No pathways have been reviewed or authored by (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) (74248)