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Details on Person PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose

Class:IdReaction:74242
_displayNamePNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose
_doReleaseTRUE
_timestamp2025-12-10 22:49:59
catalystActivity[CatalystActivity:74238] purine-nucleoside phosphorylase activity of PNP trimer [cytosol]
catalystActivityReference[CatalystActivityReference:9643298] purine-nucleoside phosphorylase activity of NP trimer [cytosol] Characterization of purine nucleoside phosphorylase from human granulocytes and its metabolism of deoxyribonucleosides
compartment[Compartment:70101] cytosol
created[InstanceEdit:74183] Jassal, B, 2003-07-17 08:31:43
crossReference[DatabaseIdentifier:9976332] RHEA:27647
[DatabaseIdentifier:9976347] RHEA:27751
input[SimpleEntity:29372] Pi [cytosol]
[DefinedSet:500172] Ino, dI [cytosol]
literatureReference[LiteratureReference:112023] Characterization of purine nucleoside phosphorylase from human granulocytes and its metabolism of deoxyribonucleosides
[LiteratureReference:112027] A human purine nucleoside phosphorylase deficiency caused by a single base change
[LiteratureReference:112018] Three-dimensional structure of human erythrocytic purine nucleoside phosphorylase at 3.2 A resolution
modified[InstanceEdit:76541] D'Eustachio, P, 2003-10-09 12:23:00
[InstanceEdit:76579] D'Eustachio, P, 2003-10-11 14:30:00
[InstanceEdit:76607] D'Eustachio, P, 2003-10-11 16:03:00
[InstanceEdit:112010] D'Eustachio, P, 2004-03-31 17:07:00
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:500249] D'Eustachio, P, 2010-02-01
[InstanceEdit:500257] D'Eustachio, P, 2010-02-01
[InstanceEdit:504063] D'Eustachio, P, 2010-02-05
[InstanceEdit:504071] D'Eustachio, P, 2010-02-07
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:8956390] D'Eustachio, Peter, 2017-01-22
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9735771] D'Eustachio, Peter, 2021-07-02
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9976335] D'Eustachio, Peter, 2025-12-10
namePNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose
inosine + phosphate => alpha-D-ribose 1-phosphate + hypoxanthine
2'-deoxyinosine + phosphate => 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine
output[SimpleEntity:113599] Hyp [cytosol]
[DefinedSet:500244] R1P, dRibP [cytosol]
precedingEvent
releaseDate2004-07-06
reverseReaction
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358859] R-HSA-74242.7
summation[Summation:178306] Cytosolic purine nucleoside phosphorylase (PNP) trimer catal...
(hasEvent)[Pathway:74259] Purine catabolism [Homo sapiens]
(inferredFrom)[Reaction:421174] inosine + orthophosphate <=> hypoxanthine + D-ribose 1-phosphate [Gallus gallus]
(normalReaction)[FailedReaction:9735775] Defective PNP does not convert (deoxy)inosine to hypoxanthine and (deoxy)ribose [Homo sapiens]
(precedingEvent)[Reaction:74247] XDH oxidizes hypoxanthine to form xanthine [Homo sapiens]
[Reaction:9727347] XDH dehydrogenates hypoxanthine to form xanthine [Homo sapiens]
[FailedReaction:9734274] Defective HPRT1 does not convert guanine or hypoxanthine to GMP or IMP [Homo sapiens]
(replacementInstances)[_Deleted:500251] Deletion of instance: 112017
[_Deleted:500252] Deletion of instance: 74239
(reverseReaction)[Reaction:112033] PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose-1-phosphate to (deoxy)inosine [Homo sapiens]
(updatedInstance)[_UpdateTracker:9775487] Update Tracker - [Reaction:74242] PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose - v79:[modifyText]
[_UpdateTracker:9775629] Update Tracker - [Reaction:74242] PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose - v78:[modifyText]
[_UpdateTracker:9791046] Update Tracker - [Reaction:74242] PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose - v32:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
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