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Details on Person ADA catalyzes the deamination of (deoxy)adenosine

Class:IdReaction:74241
_displayNameADA catalyzes the deamination of (deoxy)adenosine
_doReleaseTRUE
_timestamp2025-12-16 18:01:18
catalystActivity[CatalystActivity:74234] deaminase activity of ADA [cytosol]
catalystActivityReference[CatalystActivityReference:9643062] deaminase activity of ADA [cytosol] Mutant human adenosine deaminase alleles and their expression by transfection into fibroblasts
compartment[Compartment:70101] cytosol
created[InstanceEdit:74183] Jassal, B, 2003-07-17 08:31:43
crossReference[DatabaseIdentifier:9976251] RHEA:24409
[DatabaseIdentifier:9976254] RHEA:28191
input[DefinedSet:500173] Ade-Rib, dA [cytosol]
[SimpleEntity:29356] H2O [cytosol]
[SimpleEntity:70106] H+ [cytosol]
internalReviewed[InstanceEdit:9977060] D'Eustachio, Peter, 2025-12-16
literatureReference[LiteratureReference:200141] Mutant human adenosine deaminase alleles and their expression by transfection into fibroblasts
modified[InstanceEdit:76579] D'Eustachio, P, 2003-10-11 14:30:00
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:200032] D'Eustachio, P, 2007-07-13 20:48:01
[InstanceEdit:500174] D'Eustachio, P, 2010-02-01
[InstanceEdit:500179] D'Eustachio, P, 2010-02-01
[InstanceEdit:504063] D'Eustachio, P, 2010-02-05
[InstanceEdit:504071] D'Eustachio, P, 2010-02-07
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:8956390] D'Eustachio, Peter, 2017-01-22
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9734727] D'Eustachio, Peter, 2021-06-18
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9976255] D'Eustachio, Peter, 2025-12-09
[InstanceEdit:9977061] D'Eustachio, Peter, 2025-12-16
[InstanceEdit:9977063] D'Eustachio, Peter, 2025-12-16
nameADA catalyzes the deamination of (deoxy)adenosine
adenosine + H2O + H(+) => inosine + NH4(+)
2'-deoxyadenosine + H2O + H(+) => 2'-deoxyinosine + NH4(+)
(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH4+ (ADA)
output[DefinedSet:500172] Ino, dI [cytosol]
[SimpleEntity:31633] NH4+ [cytosol]
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2004-07-06
reviewed[InstanceEdit:9977064] D'Eustachio, Peter, 2025-12-16
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:360843] R-HSA-74241.7
structureModified[InstanceEdit:9976255] D'Eustachio, Peter, 2025-12-09
summation[Summation:178260] Cytosolic adenosine deaminase (ADA) catalyzes the hydrolysis...
(hasEvent)[Pathway:74217] Purine salvage [Homo sapiens]
(normalReaction)[FailedReaction:9734745] Defective ADA does not deaminate (deoxy)adenosine [Homo sapiens]
(precedingEvent)[Reaction:74242] PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose [Homo sapiens]
(replacementInstances)[_Deleted:500176] Deletion of instance: 74235
(updatedInstance)[_UpdateTracker:9781584] Update Tracker - [Reaction:74241] ADA catalyzes the deamination of (deoxy)adenosine - v60:[add_removeOutput]
[_UpdateTracker:9791080] Update Tracker - [Reaction:74241] ADA catalyzes the deamination of (deoxy)adenosine - v32:[add_removeInput, add_removeOutput, modifyText]
[_UpdateTracker:9792396] Update Tracker - [Reaction:74241] ADA catalyzes the deamination of (deoxy)adenosine - v22:[addLiteratureReference]
[_UpdateTracker:9984672] Update Tracker - [Reaction:74241] ADA catalyzes the deamination of (deoxy)adenosine - v96:[removeInput]
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