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Details on Person (d)AMP + ATP <=> (d)ADP + ADP (AK1)

Class:Id	Reaction:74220
_displayName	(d)AMP + ATP <=> (d)ADP + ADP (AK1)
_doRelease	TRUE
_timestamp	2025-12-02 23:58:44
catalystActivity	[CatalystActivity:73829] AMP kinase activity of Adenylate Kinase [cytosol]
catalystActivityReference	[CatalystActivityReference:9643410] adenylate kinase activity of Adenylate Kinase [cytosol] AMP (dAMP) kinase from human erythrocytes
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:74183] Jassal, B, 2003-07-17 08:31:43
crossReference	[DatabaseIdentifier:9975771] RHEA:12974 [DatabaseIdentifier:9975772] RHEA:23101
input	[DefinedSet:500088] (d)AMP [cytosol] [SimpleEntity:113592] ATP [cytosol]
literatureReference	[LiteratureReference:110126] AMP (dAMP) kinase from human erythrocytes [LiteratureReference:200272] Human adenylate kinase deficiency associated with hemolytic anemia. A single base substitution affecting solubility and catalytic activity of the cytosolic adenylate kinase.
modified	[InstanceEdit:74183] Jassal, B, 2003-07-17 08:31:43 [InstanceEdit:74479] D'Eustachio, P, 2003-07-22 16:21:00 [InstanceEdit:110076] D'Eustachio, P, 2004-01-28 17:55:00 [InstanceEdit:110253] D'Eustachio, P, 0000-00-00 00:00:00 [InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:352538] D'Eustachio, P, 2008-06-03 20:06:10 [InstanceEdit:352541] D'Eustachio, P, 2008-06-03 20:10:55 [InstanceEdit:500086] D'Eustachio, P, 2010-01-30 [InstanceEdit:504063] D'Eustachio, P, 2010-02-05 [InstanceEdit:504071] D'Eustachio, P, 2010-02-07 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8956390] D'Eustachio, Peter, 2017-01-22 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9975767] D'Eustachio, Peter, 2025-12-02
name	(d)AMP + ATP <=> (d)ADP + ADP (AK1) AMP + ATP => 2 ADP dAMP + ATP => dADP + ADP
output	[DefinedSet:500087] (d)ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:73828] adenylosuccinate => adenosine 5'-monophosphate + fumarate [Homo sapiens] [Reaction:111524] IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] [Homo sapiens] [Reaction:109624] (2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) [Homo sapiens]
releaseDate	2004-07-06
reverseReaction	[Reaction:110141] (d)ADP + ADP <=> (d)AMP + ATP (AK1) [Homo sapiens] [Reaction:74220] (d)AMP + ATP <=> (d)ADP + ADP (AK1) [Homo sapiens]
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360102] R-HSA-74220.7
summation	[Summation:178434] Cytosolic adenylate kinase 1 (AK1) catalyzes the reversible ...
(hasEvent)	[Pathway:499943] Interconversion of nucleotide di- and triphosphates [Homo sapiens]
(precedingEvent)	[Reaction:163215] SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane [Homo sapiens] [Reaction:5672027] ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane [Homo sapiens]
(replacementInstances)	[_Deleted:352540] Deletion of instance: 73830 [_Deleted:500090] Deletion of instances: 110136, 74229 [_Deleted:500092] Deletion of instance: 110123
(reverseReaction)	[Reaction:110141] (d)ADP + ADP <=> (d)AMP + ATP (AK1) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9791022] Update Tracker - [Reaction:74220] (d)AMP + ATP <=> (d)ADP + ADP (AK1) - v32:[addLiteratureReference, addOutput, add_removeInput, modifyText] [_UpdateTracker:9791827] Update Tracker - [Reaction:74220] (d)AMP + ATP <=> (d)ADP + ADP (AK1) - v25:[add_removeLiteratureReference, modifyText]
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