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Details on Person APRT catalyzes the conversion of adenine to AMP

Class:Id	Reaction:74213
_displayName	APRT catalyzes the conversion of adenine to AMP
_doRelease	TRUE
_timestamp	2025-12-09 20:34:44
catalystActivity	[CatalystActivity:74212] adenine phosphoribosyltransferase activity of APRT dimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9734726] adenine phosphoribosyltransferase activity of APRT dimer [cytosol] Structural complexes of human adenine phosphoribosyltransferase reveal novel features of the APRT catalytic mechanism
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:74183] Jassal, B, 2003-07-17 08:31:43
crossReference	[DatabaseIdentifier:9976231] RHEA:16611
input	[SimpleEntity:83951] Ade [cytosol] [SimpleEntity:73566] PRPP [cytosol]
literatureReference	[LiteratureReference:200037] Human adenine phosphoribosyltransferase. Affinity purification, subunit structure, amino acid composition, and peptide mapping. [LiteratureReference:9734723] Structural complexes of human adenine phosphoribosyltransferase reveal novel features of the APRT catalytic mechanism
modified	[InstanceEdit:74479] D'Eustachio, P, 2003-07-22 16:21:00 [InstanceEdit:76579] D'Eustachio, P, 2003-10-11 14:30:00 [InstanceEdit:164635] D'Eustachio, P, 2005-06-08 20:24:55 [InstanceEdit:200032] D'Eustachio, P, 2007-07-13 20:48:01 [InstanceEdit:504063] D'Eustachio, P, 2010-02-05 [InstanceEdit:504071] D'Eustachio, P, 2010-02-07 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9731667] D'Eustachio, Peter, 2021-05-21 [InstanceEdit:9734180] D'Eustachio, Peter, 2021-06-15 [InstanceEdit:9734727] D'Eustachio, Peter, 2021-06-18 [InstanceEdit:9748646] D'Eustachio, Peter, 2021-07-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9976236] D'Eustachio, Peter, 2025-12-09
name	APRT catalyzes the conversion of adenine to AMP 5-phospho-alpha-D-ribose 1-diphosphate + adenine => AMP + diphosphate Adenine + PRPP => AMP + PPi
output	[SimpleEntity:76577] AMP [cytosol] [SimpleEntity:111294] PPi [cytosol]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361257] R-HSA-74213.5
summation	[Summation:178383] Cytosolic APRT dimer catalyzes the reaction of adenine and 5...
(hasEvent)	[Pathway:74217] Purine salvage [Homo sapiens]
(inferredFrom)	[Reaction:1113154] Adenine + PRPP => AMP + PPi [Oryza sativa]
(normalReaction)	[FailedReaction:9734193] Defective APRT does not convert adenine to AMP [Homo sapiens]
(orthologousEvent)	[Reaction:1113154] Adenine + PRPP => AMP + PPi [Oryza sativa]
(precedingEvent)	[Reaction:71732] PPA1 hydrolyzes pyrophosphate to orthophosphate [Homo sapiens] [Reaction:76590] AMP + H2O => IMP + NH4+ (AMPD) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775590] Update Tracker - [Reaction:74213] APRT catalyzes the conversion of adenine to AMP - v78:[addLiteratureReference, modifyText] [_UpdateTracker:9790108] Update Tracker - [Reaction:74213] APRT catalyzes the conversion of adenine to AMP - v35:[modifyText] [_UpdateTracker:9792204] Update Tracker - [Reaction:74213] APRT catalyzes the conversion of adenine to AMP - v22:[addLiteratureReference]
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