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Details on Person HMG CoA => acetoacetic acid + acetyl CoA

Class:Id	Reaction:74180
_displayName	HMG CoA => acetoacetic acid + acetyl CoA
_doRelease	TRUE
_timestamp	2016-11-10 00:55:27
catalystActivity	[CatalystActivity:74179] hydroxymethylglutaryl-CoA lyase activity of HMGCL dimer [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:74171] Gopinathrao, G, 2003-07-16 00:00:00
input	[SimpleEntity:73917] HMG CoA [mitochondrial matrix]
literatureReference	[LiteratureReference:200255] 3-Hydroxy-3-methylglutaryl coenzyme A lyase (HL). Cloning of human and chicken liver HL cDNAs and characterization of a mutation causing human HL deficiency.
modified	[InstanceEdit:73908] Gopinathrao, G, 2003-08-20 08:52:29 [InstanceEdit:74168] Gopinathrao, G, 2003-07-16 00:00:00 [InstanceEdit:77107] Joshi-Tope, G, 2003-10-16 15:07:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:200252] D'Eustachio, P, 2007-07-16 20:10:20 [InstanceEdit:549341] D'Eustachio, P, 2010-03-20 [InstanceEdit:1433611] D'Eustachio, P, 2011-07-11 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	HMG CoA => acetoacetic acid + acetyl CoA
output	[SimpleEntity:113559] Ac-CoA [mitochondrial matrix] [SimpleEntity:73909] ACA [mitochondrial matrix]
precedingEvent	[Reaction:73918] acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH [Homo sapiens] [Reaction:73916] 2 acetyl-CoA <=> acetoacetyl-CoA + CoA [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361474] R-HSA-74180.3
summation	[Summation:178863] Hydroxymethylglutaryl-CoA lyase dimer (HMGCL) in the mitocho...
(hasEvent)	[Pathway:77111] Synthesis of Ketone Bodies [Homo sapiens]
(precedingEvent)	[Reaction:73912] acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9789307] Update Tracker - [Reaction:74180] HMG CoA => acetoacetic acid + acetyl CoA - v38:[modifyText] [_UpdateTracker:9790707] Update Tracker - [Reaction:74180] HMG CoA => acetoacetic acid + acetyl CoA - v33:[add_removeOutput] [_UpdateTracker:9792233] Update Tracker - [Reaction:74180] HMG CoA => acetoacetic acid + acetyl CoA - v22:[addLiteratureReference]
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No pathways have been reviewed or authored by HMG CoA => acetoacetic acid + acetyl CoA (74180)