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Details on Person PDE (phosphodiesterase) is made of two catalytic subunits an...
| Class:Id | Summation:74148 |
|---|---|
| _displayName | PDE (phosphodiesterase) is made of two catalytic subunits an... |
| _timestamp | 2003-10-06 10:40:08 |
| created | [InstanceEdit:74470] Carleton, KL, 2003-07-22 11:02:31 |
| modified | [InstanceEdit:74163] Joshi-Tope, G, 2003-07-15 16:33:00 [InstanceEdit:74399] Schmidt, EE, 2003-07-22 03:52:09 [InstanceEdit:74823] Schmidt, EE, 2003-08-20 08:52:29 [InstanceEdit:74921] Carleton, KL, 2003-07-30 11:40:37 [InstanceEdit:76256] Schmidt, EE, 2003-10-06 06:37:17 |
| text | PDE (phosphodiesterase) is made of two catalytic subunits and two inhibitory subunits. One of the catalytic subunits can be activated by binding of Gta-GTP to the associated inhibitory (PDEg) subunit. Although there are two inhibitory subunits, the second site does not seem to be activated by Gta-GTP binding as the PDEg interaction with PDEab is too strong (check on this). The activated transducin alpha subunit (Gta-GTP) binds to the gamma subunit of the PDE holoenzyme. This removes the inhibition of the PDE gamma subunit and enables the catalytic subunits of PDE to hydrolyze cGMP. |
| (summation) | [Pathway:74079] PDE activation [Bos taurus] |
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