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Details on Person UniProt:P02699 RHO
| Class:Id | ReferenceGeneProduct:74086 |
|---|---|
| _chainChangeLog | chain:1-348 added on Fri February 6 2015 |
| _displayName | UniProt:P02699 RHO |
| _timestamp | 2024-08-09 19:41:45 |
| chain | chain:1-348 |
| checksum | 33FDA196803E81F3 |
| comment | FUNCTION Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins (PubMed:10926528, PubMed:11972040, PubMed:12044163, PubMed:16586416, PubMed:16908857, PubMed:17060607, PubMed:17449675, PubMed:18818650, PubMed:21389983, PubMed:22198838, PubMed:23579341, PubMed:25205354, PubMed:27458239). Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (PubMed:1396673, PubMed:15111114).SUBUNIT Homodimer (PubMed:18563085, PubMed:23303210). May form a complex composed of RHO, GRK1 and RCVRN in a Ca(2+)-dependent manner; RCVRN prevents the interaction between GRK1 and RHO (PubMed:17020884). Interacts with GRK1 (By similarity). Interacts (phosphorylated form) with SAG (PubMed:15111114, PubMed:15351781, PubMed:23579341, PubMed:25205354, PubMed:26200343). Interacts with GNAT1 (PubMed:18818650, PubMed:21389983, PubMed:23303210, PubMed:23579341, PubMed:26526852, PubMed:28655769). Interacts with GNAT3 (PubMed:22198838, PubMed:27458239). SAG and G-proteins compete for a common binding site (By similarity). Interacts with PRCD; the interaction promotes PRCD stability (PubMed:27509380). Forms a complex with ASAP1 and ARF4 (PubMed:25673879). Forms a complex with ASAP1, RAB11A, Rabin8/RAB3IP, ARF4 and RAB11FIP3; the complex regulates Golgi-to-cilia rhodopsin/RHO transport in photoreceptors (PubMed:25673879).INTERACTION Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia.TISSUE SPECIFICITY Expressed in rod-shaped photoreceptor cells in the retina that mediate vision in dim light (at protein level).PTM Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.PTM Contains one covalently linked retinal chromophore. Upon light absorption, the covalently bound 11-cis-retinal is converted to all-trans-retinal. After hydrolysis of the Schiff base and release of the covalently bound all-trans-retinal, active rhodopsin is regenerated by binding of a fresh molecule of 11-cis-retinal.SIMILARITY Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. |
| description | recommendedName: Rhodopsin |
| geneName | RHO |
| identifier | P02699 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Cell projection Chromophore Direct protein sequencing Disulfide bond G-protein coupled receptor Glycoprotein Lipoprotein Membrane Metal-binding Palmitate Phosphoprotein Photoreceptor protein Receptor Reference proteome Retinal protein Sensory transduction Transducer Transmembrane Transmembrane helix Vision Zinc |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9666080] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 |
| name | RHO |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | OPSD_BOVIN |
| sequenceLength | 348 |
| species | [Species:48898] Bos taurus |
| (referenceEntity) | [EntityWithAccessionedSequence:74087] activated opsin [plasma membrane] [Bos taurus] [EntityWithAccessionedSequence:74098] Opsin [plasma membrane] [Bos taurus] [EntityWithAccessionedSequence:74545] p-S334,338,343-Rho [photoreceptor disc membrane] [Bos taurus] [EntityWithAccessionedSequence:2565923] Rho [photoreceptor disc membrane] [Bos taurus] [EntityWithAccessionedSequence:5623403] Rho [Golgi membrane] [Bos taurus] |
| (referenceSequence) | [ModifiedResidue:74543] O-phospho-L-serine at 334 [ModifiedResidue:74544] O-phospho-L-threonine at unknown position [ModifiedResidue:2581514] O-phospho-L-serine at 338 [ModifiedResidue:2581515] O-phospho-L-serine at 343 |
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No pathways have been reviewed or authored by UniProt:P02699 RHO (74086)
