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Details on Person UniProt:P02698 GNGT1
| Class:Id | ReferenceGeneProduct:74067 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-71 added on Fri February 6 2015;propeptide:72-74 added on Fri February 6 2015;initiator methionine:1 for 74067 removed on Fri Nov 03 2023;initiator methionine: for 74067 added on Fri Nov 03 2023;initiator methionine: for 74067 removed on Fri Aug 15 2025;initiator methionine:1 for 74067 added on Fri Aug 15 2025 |
| _displayName | UniProt:P02698 GNGT1 |
| _timestamp | 2025-08-15 21:45:26 |
| chain | initiator methionine:1 chain:2-71 propeptide:72-74 |
| checksum | B12B580FABDB1C05 |
| comment | FUNCTION Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.SUBUNIT G proteins are composed of 3 units, alpha, beta and gamma.SUBCELLULAR LOCATION Retinal rod outer segment.SIMILARITY Belongs to the G protein gamma family.CAUTION In PubMed:3917402 the authors propose that Cys-36 and Cys-37 are disulfide bonded because they could not be observed during peptide sequencing, but were observed after reduction by dithiothreitol and reaction with labeled iodoacetamide. The crystallographic structures do not support these cysteines being disulfide bonded. Artifactual oxidation and some other cysteine modifications might be consistent with these observations. |
| description | recommendedName: Guanine nucleotide-binding protein G(T) subunit gamma-T1 alternativeName: Transducin gamma chain |
| geneName | GNGT1 |
| identifier | P02698 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell membrane Direct protein sequencing Lipoprotein Membrane Methylation Prenylation Reference proteome Transducer |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | GNGT1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | GBG1_BOVIN |
| sequenceLength | 74 |
| species | [Species:48898] Bos taurus |
| (referenceEntity) | [EntityWithAccessionedSequence:74068] G protein gamma subunit [Bos taurus] [EntityWithAccessionedSequence:2530498] Gngt1 [photoreceptor disc membrane] [Bos taurus] |
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No pathways have been reviewed or authored by UniProt:P02698 GNGT1 (74067)
