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Details on Person GNAT1-GTP binds PDE6 and activates it

Class:Id	Reaction:74065
_displayName	GNAT1-GTP binds PDE6 and activates it
_doRelease	TRUE
_timestamp	2013-05-31 09:47:41
authored	[InstanceEdit:73925] Schmidt, EE, 2003-07-11 09:09:49
compartment	[Compartment:2514888] photoreceptor disc membrane [Compartment:70101] cytosol
created	[InstanceEdit:74965] Carleton, KL, 2003-07-31 08:44:54
edited	[InstanceEdit:2470272] Jassal, Bijay, 2012-09-18
inferredFrom	[Reaction:74066] Gnat1-GTP binds Pde6 and activates it [Bos taurus]
input	[Complex:74055] PDE6 [photoreceptor disc membrane] [Homo sapiens] [Complex:74049] GNAT1-GTP [photoreceptor disc membrane] [Homo sapiens]
literatureReference	[LiteratureReference:74432] Molecular characterization of human and bovine rod photoreceptor cGMP phosphodiesterase alpha-subunit and chromosomal localization of the human gene [LiteratureReference:2534118] Genomic organization and complete sequence of the human gene encoding the beta-subunit of the cGMP phosphodiesterase and its localisation to 4p 16.3 [LiteratureReference:74440] Isolation and characterization of cDNA encoding the gamma-subunit of cGMP phosphodiesterase in human retina
modified	[InstanceEdit:74163] Joshi-Tope, G, 2003-07-15 16:33:00 [InstanceEdit:74964] Schmidt, EE, 2003-07-31 08:44:50 [InstanceEdit:2470272] Jassal, Bijay, 2012-09-18 [InstanceEdit:2514885] Jassal, B, 2012-10-11 [InstanceEdit:2528988] Jassal, B, 2012-10-15 [InstanceEdit:2534108] Jassal, B, 2012-10-24 [InstanceEdit:3222467] Jassal, B, 2013-03-20 [InstanceEdit:3270611] Jassal, Bijay, 2013-04-11 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GNAT1-GTP binds PDE6 and activates it
output	[Complex:74056] GNAT1-GTP:PDE6 [photoreceptor disc membrane] [Homo sapiens]
precedingEvent	[Reaction:2485182] Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 [Homo sapiens] [Reaction:2485180] MII catalyses GDP/GTP exchange on Gt [Homo sapiens]
regulatedBy	[NegativeRegulation:5603168] Negative regulation by 'GNAT1-GDP [photoreceptor disc membrane]'
releaseDate	2013-06-11
reviewed	[InstanceEdit:3270610] Makino, C, 2013-04-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3654471] R-HSA-74065.3
summation	[Summation:2514876] The membrane associated cGMP phosphodiesterase 6 (PDE6) is a...
(hasEvent)	[Pathway:74080] PDE activation [Homo sapiens] [Pathway:2485179] Activation of the phototransduction cascade [Homo sapiens]
(normalReaction)	[FailedReaction:2514900] Defective GNAT1 does not activate PDE6 [Homo sapiens]
(precedingEvent)	[Reaction:74059] PDE6 hydrolyses cGMP to GMP [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9785975] Update Tracker - [Reaction:74065] GNAT1-GTP binds PDE6 and activates it - v50:[add_removeRegulator, modifyText]
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