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Details on Person PDE6 hydrolyses cGMP to GMP

Class:Id	Reaction:74059
_displayName	PDE6 hydrolyses cGMP to GMP
_doRelease	TRUE
_timestamp	2013-12-10 11:36:35
authored	[InstanceEdit:73925] Schmidt, EE, 2003-07-11 09:09:49
catalystActivity	[CatalystActivity:2514875] 3',5'-cyclic-GMP phosphodiesterase activity of GNAT1-GTP:PDE6 [photoreceptor disc membrane]
compartment	[Compartment:2514888] photoreceptor disc membrane [Compartment:70101] cytosol
created	[InstanceEdit:74965] Carleton, KL, 2003-07-31 08:44:54
edited	[InstanceEdit:2534149] Jassal, B, 2012-10-24
input	[SimpleEntity:30991] cGMP [cytosol] [SimpleEntity:29356] H2O [cytosol]
literatureReference	[LiteratureReference:2534118] Genomic organization and complete sequence of the human gene encoding the beta-subunit of the cGMP phosphodiesterase and its localisation to 4p 16.3 [LiteratureReference:74440] Isolation and characterization of cDNA encoding the gamma-subunit of cGMP phosphodiesterase in human retina [LiteratureReference:74432] Molecular characterization of human and bovine rod photoreceptor cGMP phosphodiesterase alpha-subunit and chromosomal localization of the human gene [LiteratureReference:3262435] Light activation of phosphodiesterase activity in retinal rod outer segments [LiteratureReference:3262445] Light and dark active phosphodiesterase regulation in salamander rods [LiteratureReference:3262446] Regulation of cyclic GMP metabolism in toad photoreceptors. Definition of the metabolic events subserving photoexcited and attenuated states [LiteratureReference:3262436] Light-regulated guanosine 3',5'-monophosphate phosphodiesterase of bovine retina [LiteratureReference:3262478] Control of light-sensitive current in salamander rods [LiteratureReference:3262465] Regulation of cyclic nucleotide concentrations in photoreceptors: an ATP-dependent stimulation of cyclic nucleotide phosphodiesterase by light [LiteratureReference:3262441] Molecular origin of continuous dark noise in rod photoreceptors [LiteratureReference:3262468] Reciprocal control of retinal rod cyclic GMP phosphodiesterase by its gamma subunit and transducin
modified	[InstanceEdit:74163] Joshi-Tope, G, 2003-07-15 16:33:00 [InstanceEdit:73996] Schmidt, EE, 2003-08-20 08:52:29 [InstanceEdit:74964] Schmidt, EE, 2003-07-31 08:44:50 [InstanceEdit:113653] Schmidt, EE, 2004-06-14 05:50:20 [InstanceEdit:2470272] Jassal, Bijay, 2012-09-18 [InstanceEdit:2514885] Jassal, B, 2012-10-11 [InstanceEdit:2534108] Jassal, B, 2012-10-24 [InstanceEdit:3223221] Jassal, Bijay, 2013-03-25 [InstanceEdit:3262437] Jassal, Bijay, 2013-04-10 [InstanceEdit:3270611] Jassal, Bijay, 2013-04-11 [InstanceEdit:3632877] Jassal, Bijay, 2013-05-28 [InstanceEdit:5211379] Jassal, B, 2013-12-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PDE6 hydrolyses cGMP to GMP
output	[SimpleEntity:113578] GMP [cytosol]
precedingEvent	[Reaction:74065] GNAT1-GTP binds PDE6 and activates it [Homo sapiens] [Reaction:2485182] Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 [Homo sapiens]
releaseDate	2013-06-11
reviewed	[InstanceEdit:3270610] Makino, C, 2013-04-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3654304] R-HSA-74059.2
summation	[Summation:2514878] Phosphodiesterase 6 (PDE6, Pittler et al. 1990, Tuteja et al...
(hasEvent)	[Pathway:74109] Activation [Homo sapiens] [Pathway:2485179] Activation of the phototransduction cascade [Homo sapiens]
(precedingEvent)	[Reaction:2514865] cGMP dissociates from CNG channels [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9786756] Update Tracker - [Reaction:74059] PDE6 hydrolyses cGMP to GMP - v48:[modifyText, removeRegulator]
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