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Details on Person UniProt:P04695 GNAT1
| Class:Id | ReferenceGeneProduct:74040 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-350 added on Sat February 7 2015;initiator methionine:1 for 74040 removed on Fri Nov 03 2023;initiator methionine: for 74040 added on Fri Nov 03 2023;initiator methionine: for 74040 removed on Fri Aug 15 2025;initiator methionine:1 for 74040 added on Fri Aug 15 2025 |
| _displayName | UniProt:P04695 GNAT1 |
| _timestamp | 2025-08-15 21:30:19 |
| chain | initiator methionine:1 chain:2-350 |
| checksum | 36F0B4630EFBD7DF |
| comment | FUNCTION Functions as a signal transducer for the rod photoreceptor RHO (PubMed:21285355, PubMed:23303210, PubMed:28655769, PubMed:8259210). Required for normal RHO-mediated light perception by the retina (By similarity). Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs), such as the photoreceptor RHO. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:21285355, PubMed:28655769, PubMed:7969474, PubMed:8208289, PubMed:8259210). Activated RHO promotes GDP release and GTP binding (PubMed:21285355, PubMed:28655769). Signaling is mediated via downstream effector proteins, such as cGMP-phosphodiesterase (PubMed:21285355).SUBUNIT Heterotrimeric G proteins are composed of 3 subunits alpha, beta and gamma (PubMed:21285355, PubMed:23303210, PubMed:28655769). The alpha chain contains the guanine nucleotide binding site (PubMed:21285355, PubMed:7969474, PubMed:8208289, PubMed:8259210). Interacts with RHO (PubMed:18818650, PubMed:21285355, PubMed:21389983, PubMed:21389988, PubMed:23303210, PubMed:23579341, PubMed:28655769, PubMed:9539726). Interacts with RGS9 and PDE6G (PubMed:11234020). Interacts (when myristoylated) with UNC119; interaction is required for localization in sensory neurons (By similarity).INTERACTION Localizes mainly in the outer segment in the dark-adapted state, whereas is translocated to the inner part of the photoreceptors in the light-adapted state. During dark-adapted conditions, in the presence of UNC119 mislocalizes from the outer segment to the inner part of rod photoreceptors which leads to decreased photoreceptor damage caused by light.TISSUE SPECIFICITY Rod. |
| description | recommendedName: Guanine nucleotide-binding protein G(t) subunit alpha-1 alternativeName: Transducin alpha-1 chain |
| geneName | GNAT1 |
| identifier | P04695 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell projection Direct protein sequencing GTP-binding Lipoprotein Magnesium Membrane Metal-binding Myristate Nucleotide-binding Phosphoprotein Reference proteome Sensory transduction Transducer Vision |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9607352] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9645038] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | GNAT1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | GNAT1_BOVIN |
| sequenceLength | 350 |
| species | [Species:48898] Bos taurus |
| (referenceEntity) | [EntityWithAccessionedSequence:74041] G protein alpha subunit [Bos taurus] [EntityWithAccessionedSequence:2530518] Gnat1 [photoreceptor disc membrane] [Bos taurus] [EntityWithAccessionedSequence:2534068] N-(C12:0)-GNAT1 [photoreceptor disc membrane] [Bos taurus] [EntityWithAccessionedSequence:2534079] N-(C14:1)-GNAT1 [photoreceptor disc membrane] [Bos taurus] [EntityWithAccessionedSequence:2534086] N-(C14:2)-GNAT1 [photoreceptor disc membrane] [Bos taurus] |
| (referenceSequence) | [GroupModifiedResidue:2534010] N-(cis-delta 5)-tetradecaenoylglycine (C14:1 group) at 2 [GroupModifiedResidue:2534016] modified glycine residue (lauroyl group) at 2 [GroupModifiedResidue:2534071] N-(cis,cis-delta 5,delta 8)-tetradecadienoylglycine (C14:2 group) at 2 |
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No pathways have been reviewed or authored by UniProt:P04695 GNAT1 (74040)
