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Details on Person UniProt:P11541 PDE6A
| Class:Id | ReferenceGeneProduct:74033 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-856 added on Fri February 6 2015;propeptide:857-859 added on Fri February 6 2015;initiator methionine:1 for 74033 removed on Fri Nov 03 2023;initiator methionine: for 74033 added on Fri Nov 03 2023;initiator methionine: for 74033 removed on Fri Aug 15 2025;initiator methionine:1 for 74033 added on Fri Aug 15 2025 |
| _displayName | UniProt:P11541 PDE6A |
| _timestamp | 2025-08-15 21:02:07 |
| chain | initiator methionine:1 chain:2-856 propeptide:857-859 |
| checksum | 701CB148F73A1303 |
| comment | FUNCTION Rod-specific cGMP phosphodiesterase that catalyzes the hydrolysis of 3',5'-cyclic GMP. This protein participates in processes of transmission and amplification of the visual signal.CATALYTIC ACTIVITY 3',5'-cyclic GMP + H2O = GMP + H(+)COFACTOR Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.SUBUNIT Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.SUBCELLULAR LOCATION Belongs to the cyclic nucleotide phosphodiesterase family. |
| description | recommendedName: fullName evidence="2"Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha shortName: GMP-PDE alpha ecNumber evidence="2"3.1.4.35 alternativeName: PDE V-B1 |
| geneName | PDE6A PDEA |
| identifier | P11541 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Cell membrane Cell projection cGMP Direct protein sequencing Hydrolase Lipoprotein Membrane Metal-binding Methylation Prenylation Reference proteome Repeat Sensory transduction Vision |
| modified | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | PDE6A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | PDE6A_BOVIN |
| sequenceLength | 859 |
| species | [Species:48898] Bos taurus |
| (referenceEntity) | [EntityWithAccessionedSequence:74462] S-farn-Pde6a [photoreceptor disc membrane] [Bos taurus] |
| (referenceSequence) | [ModifiedResidue:74461] S-farnesyl-L-cysteine at 855 |
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No pathways have been reviewed or authored by UniProt:P11541 PDE6A (74033)
