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Details on Person Binding of XPC complex to the damaged site on the DNA substr...
| Class:Id | Summation:73971 |
|---|---|
| _displayName | Binding of XPC complex to the damaged site on the DNA substr... |
| _timestamp | 2004-03-02 00:35:15 |
| created | [InstanceEdit:73956] Joshi-Tope, G, 2003-07-14 15:01:00 |
| modified | [InstanceEdit:110546] Gopinathrao, G, 2004-02-02 17:30:34 [InstanceEdit:111340] Gopinathrao, G, 2004-02-12 15:30:00 [InstanceEdit:111622] Gopinathrao, G, 2004-03-01 18:40:00 |
| text | Binding of XPC complex to the damaged site on the DNA substrate is followed by XPA and RPA recruitment. XPA is a metalloprotein that binds to different types of DNA damage. Binding of RPA, or Replicative protein A, a heterotrimer, initiates the formation of incision complex. This includes a serial assembly of the rest of the NER machinery consisting of TFIIH, XPG etc. Action of helicases in TFIIH complex opens up a bubble structure in the DNA template, exposing a fragment of DNA with lesion for endonuclease activity. |
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No pathways have been reviewed or authored by Binding of XPC complex to the damaged site on the DNA substr... (73971)
