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Details on Person FAS-mediated dimerization of procaspase-8

Class:Id	Reaction:73945
_displayName	FAS-mediated dimerization of procaspase-8
_doRelease	TRUE
_timestamp	2016-11-10 00:55:04
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:110071] Tschopp, J�rg, 2004-01-28
edited	[InstanceEdit:3508822] Shamovsky, V, 2013-05-17
figure	[Figure:141227] /figures/FasL_Fas_FADD_Caspase8.jpg
input	[Complex:75114] FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:57031] CASP8(1-479) [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:141158] Death receptors: signaling and modulation [LiteratureReference:2984185] Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95-mediated death or survival [LiteratureReference:1267807] Interdimer processing mechanism of procaspase-8 activation
modified	[InstanceEdit:73953] Joshi-Tope, G, 2003-07-11 17:00:03 [InstanceEdit:75141] Matthews, L, 2003-08-11 05:43:00 [InstanceEdit:75992] Matthews, L, 2003-09-10 06:00:00 [InstanceEdit:83604] Matthews, L, 2003-11-23 12:20:00 [InstanceEdit:109912] Joshi-Tope, G, 2004-01-21 22:18:55 [InstanceEdit:109917] Joshi-Tope, G, 2004-01-22 15:11:19 [InstanceEdit:110070] Joshi-Tope, G, 2004-01-28 14:40:07 [InstanceEdit:141163] Gillespie, ME, 2004-09-02 19:19:24 [InstanceEdit:141243] Gillespie, ME, 2004-09-07 03:33:39 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:2648974] D'Eustachio, P, 2012-11-21 [InstanceEdit:2671826] Shamovsky, V, 2012-11-26 [InstanceEdit:2671827] Shamovsky, V, 2012-11-26 [InstanceEdit:2984184] Shamovsky, V, 2013-01-15 [InstanceEdit:3597633] Shamovsky, V, 2013-05-22 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FAS-mediated dimerization of procaspase-8
output	[Complex:2671811] FASL:FAS receptor trimer:FADD:procaspase-8-dimer [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:83586] FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 [Homo sapiens] [Reaction:83650] FasL:Fas binds FADD [Homo sapiens]
regulatedBy	[NegativeRegulation:3465438] Negative regulation by 'FLIP(S) [cytosol]'
regulationReference	[RegulationReference:9641556] Negative regulation by 'FLIP(S) [cytosol]' NF-kappaB signals induce the expression of c-FLIP
releaseDate	2004-10-27
reviewed	[InstanceEdit:2594924] Gillespie, ME, 2012-11-19 [InstanceEdit:3597630] Pop, Cristina, Salvesen, Guy S., 2013-05-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359070] R-HSA-73945.5
summation	[Summation:178760] Monomeric caspase-8 zymogens undergo dimerization and subseq...
(hasEvent)	[Pathway:69416] Dimerization of procaspase-8 [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:139952] Caspase-8 processing in the DISC [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9787339] Update Tracker - [Reaction:73945] FAS-mediated dimerization of procaspase-8 - v45:[addRegulator] [_UpdateTracker:9787703] Update Tracker - [Reaction:73945] FAS-mediated dimerization of procaspase-8 - v44:[addInput, addLiteratureReference, add_removeOutput, modifyText]
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