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Details on Person acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH

Class:Id	Reaction:73918
_displayName	acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH
_doRelease	TRUE
_timestamp	2016-11-10 00:54:34
catalystActivity	[CatalystActivity:74170] hydroxymethylglutaryl-CoA synthase activity of HMGCS2 [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:74168] Gopinathrao, G, 2003-07-16 00:00:00
input	[SimpleEntity:73871] ACA-CoA [mitochondrial matrix] [SimpleEntity:113559] Ac-CoA [mitochondrial matrix]
literatureReference	[LiteratureReference:200268] Genetic basis of mitochondrial HMG-CoA synthase deficiency
modified	[InstanceEdit:74168] Gopinathrao, G, 2003-07-16 00:00:00 [InstanceEdit:74168] Gopinathrao, G, 2003-07-16 00:00:00 [InstanceEdit:77107] Joshi-Tope, G, 2003-10-16 15:07:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:200252] D'Eustachio, P, 2007-07-16 20:10:20 [InstanceEdit:549340] D'Eustachio, P, 2010-03-20 [InstanceEdit:6781759] Jassal, Bijay, 2015-06-02 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH
output	[SimpleEntity:73917] HMG CoA [mitochondrial matrix] [SimpleEntity:29374] CoA-SH [mitochondrial matrix]
precedingEvent	[Reaction:73916] 2 acetyl-CoA <=> acetoacetyl-CoA + CoA [Homo sapiens] [Reaction:8875071] ACSS3 ligates CoA to CH3COO- [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360099] R-HSA-73918.4
summation	[Summation:178369] Hydroxymethylglutaryl-CoA synthase tetramer (HMGCS2) in the ...
(hasEvent)	[Pathway:77111] Synthesis of Ketone Bodies [Homo sapiens]
(precedingEvent)	[Reaction:74180] HMG CoA => acetoacetic acid + acetyl CoA [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9789141] Update Tracker - [Reaction:73918] acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH - v38:[modifyText] [_UpdateTracker:9790671] Update Tracker - [Reaction:73918] acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH - v33:[addOutput] [_UpdateTracker:9792392] Update Tracker - [Reaction:73918] acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH - v22:[addLiteratureReference]
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No pathways have been reviewed or authored by acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH (73918)