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Details on Person 2 acetyl-CoA <=> acetoacetyl-CoA + CoA

Class:Id	Reaction:73916
_displayName	2 acetyl-CoA <=> acetoacetyl-CoA + CoA
_doRelease	TRUE
_timestamp	2016-11-10 00:55:00
catalystActivity	[CatalystActivity:70842] acetyl-CoA C-acetyltransferase activity of ACAT1 tetramer [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643975] acetyl-CoA C-acetyltransferase activity of ACAT1 tetramer [mitochondrial matrix] Crystallographic and kinetic studies of human mitochondrial acetoacetyl-CoA thiolase: the importance of potassium and chloride ions for its structure and function
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:74168] Gopinathrao, G, 2003-07-16 00:00:00
input	[SimpleEntity:113559] Ac-CoA [mitochondrial matrix] [SimpleEntity:113559] Ac-CoA [mitochondrial matrix]
literatureReference	[LiteratureReference:200040] 3-Ketothiolase deficiency
modified	[InstanceEdit:74168] Gopinathrao, G, 2003-07-16 00:00:00 [InstanceEdit:74168] Gopinathrao, G, 2003-07-16 00:00:00 [InstanceEdit:77107] Joshi-Tope, G, 2003-10-16 15:07:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:200032] D'Eustachio, P, 2007-07-13 20:48:01 [InstanceEdit:549340] D'Eustachio, P, 2010-03-20 [InstanceEdit:1433615] D'Eustachio, P, 2011-07-11 [InstanceEdit:8878132] Jassal, Bijay, 2016-06-30 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	2 acetyl-CoA <=> acetoacetyl-CoA + CoA
output	[SimpleEntity:73871] ACA-CoA [mitochondrial matrix] [SimpleEntity:29374] CoA-SH [mitochondrial matrix]
precedingEvent	[Reaction:8875071] ACSS3 ligates CoA to CH3COO- [Homo sapiens]
releaseDate	2004-07-06
reverseReaction	[Reaction:74181] acetoacetyl-CoA + CoA <=> 2 acetyl-CoA [Homo sapiens] [Reaction:73916] 2 acetyl-CoA <=> acetoacetyl-CoA + CoA [Homo sapiens]
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360094] R-HSA-73916.5
summation	[Summation:178254] Acetyl-CoA acetyltransferase tetramer (ACAT1) in the mitocho...
(hasEvent)	[Pathway:77111] Synthesis of Ketone Bodies [Homo sapiens]
(precedingEvent)	[Reaction:73918] acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH [Homo sapiens]
(reverseReaction)	[Reaction:74181] acetoacetyl-CoA + CoA <=> 2 acetyl-CoA [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9789151] Update Tracker - [Reaction:73916] 2 acetyl-CoA <=> acetoacetyl-CoA + CoA - v38:[modifyText] [_UpdateTracker:9792334] Update Tracker - [Reaction:73916] 2 acetyl-CoA <=> acetoacetyl-CoA + CoA - v22:[addLiteratureReference]
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No pathways have been reviewed or authored by 2 acetyl-CoA <=> acetoacetyl-CoA + CoA (73916)