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Details on Person MGMT/hAGT mediated DNA Damage Reversal

Class:Id	Reaction:73892
_displayName	MGMT/hAGT mediated DNA Damage Reversal
_doRelease	TRUE
_timestamp	2015-02-23 15:45:06
authored	[InstanceEdit:110572] Pegg, A, 2004-02-04 15:50:05
catalystActivity	[CatalystActivity:5657633] methylated-DNA-[protein]-cysteine S-methyltransferase activity of MGMT:Zn2+:6-OMeG-dsDNA [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:110572] Pegg, A, 2004-02-04 15:50:05
edited	[InstanceEdit:110574] Joshi-Tope, G, 2004-02-04 16:13:17 [InstanceEdit:5658055] Orlic-Milacic, Marija, 2014-12-16
goBiologicalProcess	[GO_BiologicalProcess:17672] DNA alkylation repair
input	[Complex:5657662] MGMT:Zn2+:6-OMeG-dsDNA [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:69939] Regulation of repair of alkylation damage in mammalian genomes. [LiteratureReference:5658021] Suicide inactivation of the E. coli O6-methylguanine-DNA methyltransferase [LiteratureReference:5658019] Crystal structure of a suicidal DNA repair protein: the Ada O6-methylguanine-DNA methyltransferase from E. coli [LiteratureReference:5658010] Active-site alkylation destabilizes human O6-alkylguanine DNA alkyltransferase [LiteratureReference:5658008] DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy
modified	[InstanceEdit:109734] Joshi-Tope, G, 2004-01-20 11:15:00 [InstanceEdit:109761] Joshi-Tope, G, 2004-01-20 14:56:22 [InstanceEdit:110073] Joshi-Tope, G, 2004-01-28 15:38:16 [InstanceEdit:110326] Joshi-Tope, G, 2004-01-30 11:28:59 [InstanceEdit:110571] Joshi-Tope, G, 2004-02-04 15:50:04 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:947484] Garapati, P V, 2010-09-08 [InstanceEdit:2671734] D'Eustachio, P, 2012-11-23 [InstanceEdit:5657608] Orlic-Milacic, Marija, 2014-12-15 [InstanceEdit:5657628] Orlic-Milacic, Marija, 2014-12-15 [InstanceEdit:5658022] Orlic-Milacic, Marija, 2014-12-16 [InstanceEdit:5674552] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:5678318] Orlic-Milacic, Marija, 2015-02-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MGMT/hAGT mediated DNA Damage Reversal
output	[GenomeEncodedEntity:5649637] dsDNA [nucleoplasm] [Homo sapiens] [Complex:5657639] MetC-MGMT:Zn2+ [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:5657651] MGMT binds alkylated DNA containing 6-O-methylguanine [Homo sapiens] [BlackBoxEvent:9732692] Triazenes produce DNA damage in the form of O6-methylguanine [Homo sapiens]
releaseDate	2004-03-06
reviewed	[InstanceEdit:110574] Joshi-Tope, G, 2004-02-04 16:13:17 [InstanceEdit:5672906] Gillespie, Marc E, 2015-02-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:5657608] Orlic-Milacic, Marija, 2014-12-15
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360930] R-HSA-73892.2
summation	[Summation:109760] MGMT, just like its E.coli homolog Ada, is an O-6-methylguan...
(hasEvent)	[Pathway:5657655] MGMT-mediated DNA damage reversal [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9785214] Update Tracker - [Reaction:73892] MGMT/hAGT mediated DNA Damage Reversal - v52:[addLiteratureReference, add_removeCatalystActivity, add_removeInput, add_removeOutput, modifyText] [_UpdateTracker:9788587] Update Tracker - [Reaction:73892] MGMT/hAGT mediated DNA Damage Reversal - v41:[modifyText] [_UpdateTracker:9788775] Update Tracker - [Reaction:73892] MGMT/hAGT mediated DNA Damage Reversal - v40:[modifyText] [_UpdateTracker:9789936] Update Tracker - [Reaction:73892] MGMT/hAGT mediated DNA Damage Reversal - v36:[modifyText] [_UpdateTracker:9790257] Update Tracker - [Reaction:73892] MGMT/hAGT mediated DNA Damage Reversal - v34:[add_removeCatalystActivity]
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No pathways have been reviewed or authored by MGMT/hAGT mediated DNA Damage Reversal (73892)