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Details on Person Assembly of RNA Polymerase I holoenzyme

Class:IdReaction:73865
_displayNameAssembly of RNA Polymerase I holoenzyme
_doReleaseTRUE
_timestamp2026-05-06 19:05:20
compartment[Compartment:7660] nucleoplasm
inferredFrom
input[EntityWithAccessionedSequence:5419289] CD3EAP [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:63494] POLR1A [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:63496] POLR1B [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:63498] POLR1C [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:63500] POLR1D [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:5419294] POLR1E [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:83713] POLR2E [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:83714] POLR2F [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:63523] POLR2H [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:63537] POLR2K [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:83715] POLR2L [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:5419290] TWISTNB [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:5419292] ZNRD1 [nucleoplasm] [Homo sapiens]
literatureReference[LiteratureReference:9987912] Cryo-EM structures of human RNA polymerase I
[LiteratureReference:9988014] Structure of the human RNA polymerase I elongation complex
[LiteratureReference:9987995] Structural insights into nuclear transcription by eukaryotic DNA-dependent RNA polymerases
[LiteratureReference:9987921] Crystal structure of the 14-subunit RNA polymerase I
[LiteratureReference:9987964] RNA polymerase I structure and transcription regulation
[LiteratureReference:9987928] Functional architecture of RNA polymerase I
[LiteratureReference:9987939] RNA polymerase I contains a TFIIF-related DNA-binding subcomplex
[LiteratureReference:9988029] TIF-IA, the factor mediating growth-dependent control of ribosomal RNA synthesis, is the mammalian homolog of yeast Rrn3p
[LiteratureReference:9987966] RNA polymerase I transcription factor Rrn3 is functionally conserved between yeast and human
[LiteratureReference:9988053] hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters
[LiteratureReference:73759] Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter.
modified[InstanceEdit:74163] Joshi-Tope, G, 2003-07-15 16:33:00
[InstanceEdit:75001] Gillespie, ME, 2003-08-07 00:00:00
[InstanceEdit:141280] Gillespie, ME, 2004-09-13 21:35:09
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:5255454] D'Eustachio, Peter, 2014-02-06
[InstanceEdit:5419295] May, Bruce, 2014-05-04
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9988360] Rothfels, Karen, 2026-05-06
nameAssembly of RNA Polymerase I holoenzyme
output[Complex:73859] RNA Polymerase I Holoenzyme [nucleoplasm] [Homo sapiens]
releaseDate2004-07-06
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:361328] R-HSA-73865.3
summation[Summation:9988346] Human RNA Polymerase I is a multisubunit complex consisting ...
(hasEvent)[Pathway:73762] RNA Polymerase I Transcription Initiation [Homo sapiens]
(inferredFrom)[Reaction:1113254] Assembly of RNA Polymerase I Holoenzyme (human) [Oryza sativa]
(orthologousEvent)[Reaction:1113254] Assembly of RNA Polymerase I Holoenzyme (human) [Oryza sativa]
(precedingEvent)[Reaction:73757] Binding of RRN3 to RNA Polymerase I [Homo sapiens]
(updatedInstance)[_UpdateTracker:9786424] Update Tracker - [Reaction:73865] Assembly of RNA Polymerase I Holoenzyme (human) - v49:[addInput, modifyText]
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