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Details on Person In parallel sequences of three reactions each, thymine is co...
| Class:Id | Summation:73837 |
|---|---|
| _displayName | In parallel sequences of three reactions each, thymine is co... |
| _timestamp | 2010-11-07 21:30:08 |
| created | [InstanceEdit:73449] Jassal, B, 2003-06-17 09:00:26 |
| modified | [InstanceEdit:74362] D'Eustachio, P, 2003-07-18 15:39:00 [InstanceEdit:75131] D'Eustachio, P, 2003-08-26 15:20:00 [InstanceEdit:84019] D'Eustachio, P, 2003-12-16 10:39:00 [InstanceEdit:909782] D'Eustachio, P, 2010-07-07 [InstanceEdit:996686] D'Eustachio, P, 2010-11-07 |
| text | In parallel sequences of three reactions each, thymine is converted to beta-aminoisobutyrate and uracil is converted to beta-alanine. Both of these molecules are excreted in human urine and appear to be normal end products of pyrimidine catabolism (Griffith 1986; Webster et al. 2001). Mitochondrial AGXT2, however, can also catalyze the transamination of both molecules with pyruvate, yielding 2-oxoacids that can be metabolized further by reactions of branched-chain amino acid and short-chain fatty acid catabolism (Tamaki et al. 2000). The importance of these reactions in normal human pyrimidine catabolism has not been well worked out. |
| (summation) | [Pathway:73621] Pyrimidine catabolism [Homo sapiens] |
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