Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate

Class:Id	Reaction:73815
_displayName	5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate
_doRelease	TRUE
_timestamp	2025-12-01 23:58:27
authored	[InstanceEdit:73784] Jassal, B, 2003-06-26 04:06:16
catalystActivity	[CatalystActivity:73791] amidophosphoribosyltransferase activity of PPAT dimer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:73784] Jassal, B, 2003-06-26 04:06:16
crossReference	[DatabaseIdentifier:9975677] RHEA:14907
edited	[InstanceEdit:165090] Jassal, B, D'Eustachio, P, 0000-00-00 00:00:00
input	[SimpleEntity:73566] PRPP [cytosol] [SimpleEntity:29472] L-Gln [cytosol] [SimpleEntity:29356] H2O [cytosol]
literatureReference	[LiteratureReference:111230] Human glutamine phosphoribosylpyrophosphate amidotransferase. Kinetic and regulatory properties [LiteratureReference:111231] Human glutamine phosphoribosylpyrophosphate amidotransferase. Two molecular forms interconvertible by purine ribonucleotides and phosphoribosylpyrophosphate [LiteratureReference:111232] Human amidophosphoribosyltransferase. An oxygen-sensitive iron-sulfur protein [LiteratureReference:111233] Molecular cloning of human amidophosphoribosyltransferase [LiteratureReference:419266] Reversible compartmentalization of de novo purine biosynthetic complexes in living cells
modified	[InstanceEdit:74183] Jassal, B, 2003-07-17 08:31:43 [InstanceEdit:75139] D'Eustachio, P, 0000-00-00 00:00:00 [InstanceEdit:111216] D'Eustachio, P, 2004-02-10 11:22:00 [InstanceEdit:111220] D'Eustachio, P, 2004-02-10 14:26:00 [InstanceEdit:111282] D'Eustachio, P, 2004-02-11 12:18:00 [InstanceEdit:111546] D'Eustachio, P, 2004-02-20 14:39:00 [InstanceEdit:143508] D'Eustachio, P, 2004-11-11 21:35:58 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:189818] D'Eustachio, P, 2006-12-06 23:20:55 [InstanceEdit:189818] D'Eustachio, P, 2006-12-06 23:20:55 [InstanceEdit:419269] D'Eustachio, P, 2009-04-29 22:27:53 [InstanceEdit:419273] D'Eustachio, P, 2009-04-29 22:49:45 [InstanceEdit:504063] D'Eustachio, P, 2010-02-05 [InstanceEdit:504071] D'Eustachio, P, 2010-02-07 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9736302] D'Eustachio, Peter, 2021-07-06 [InstanceEdit:9748647] D'Eustachio, Peter, 2021-07-23 [InstanceEdit:9765093] D'Eustachio, Peter, 2022-02-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9975689] D'Eustachio, Peter, 2025-12-01
name	5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O => 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate PRPP + H2O + L-Glutamine => 5-Phosphoribosylamine + L-Glutamate + PPi
output	[SimpleEntity:111292] PRA [cytosol] [SimpleEntity:29404] L-Glu [cytosol] [SimpleEntity:111294] PPi [cytosol]
precedingEvent	[Reaction:111215] PRPS1 dimer pyrophosphorylates R5P using dATP [Homo sapiens] [Reaction:73580] PRPS dimers pyrophosphorylate R5P using ATP [Homo sapiens] [Reaction:71306] RPIA isomerizes D-ribulose 5-phosphate to ribose 5-phosphate [Homo sapiens] [Reaction:111289] Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360438] R-HSA-73815.7
summation	[Summation:73819] Cytosolic PPAT (phosphoribosyl pyrophosphate amidotransferas...
(hasEvent)	[Pathway:73817] Purine ribonucleoside monophosphate biosynthesis [Homo sapiens]
(inferredFrom)	[Reaction:1113155] 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate [Oryza sativa]
(orthologousEvent)	[Reaction:1113155] 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate [Oryza sativa]
(precedingEvent)	[Reaction:71732] PPA1 hydrolyzes pyrophosphate to orthophosphate [Homo sapiens] [Reaction:73814] 5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9786602] Update Tracker - [Reaction:73815] 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate - v49:[removeRegulator] [_UpdateTracker:9791519] Update Tracker - [Reaction:73815] 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate - v29:[addLiteratureReference, modifyText]
[Change default viewing format]

No pathways have been reviewed or authored by 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (73815)