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Details on Person 5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi

Class:Id	Reaction:73814
_displayName	5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi
_doRelease	TRUE
_timestamp	2025-12-01 23:58:26
authored	[InstanceEdit:111318] D'Eustachio, P, 2004-02-12 15:28:00
catalystActivity	[CatalystActivity:73807] phosphoribosylamine-glycine ligase activity of GART [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:73784] Jassal, B, 2003-06-26 04:06:16
crossReference	[DatabaseIdentifier:9975683] RHEA:17454
edited	[InstanceEdit:165089] D'Eustachio, P, Jassal, B, 0000-00-00 00:00:00
input	[SimpleEntity:111292] PRA [cytosol] [SimpleEntity:29424] Gly [cytosol] [SimpleEntity:113592] ATP [cytosol]
literatureReference	[LiteratureReference:111324] De novo purine nucleotide biosynthesis: cloning of human and avian cDNAs encoding the trifunctional glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase by functional complementation in E. coli [LiteratureReference:111333] Localization of GAR transformylase in Escherichia coli and mammalian cells [LiteratureReference:419266] Reversible compartmentalization of de novo purine biosynthetic complexes in living cells
modified	[InstanceEdit:74183] Jassal, B, 2003-07-17 08:31:43 [InstanceEdit:74479] D'Eustachio, P, 2003-07-22 16:21:00 [InstanceEdit:111318] D'Eustachio, P, 2004-02-12 15:28:00 [InstanceEdit:111546] D'Eustachio, P, 2004-02-20 14:39:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:419269] D'Eustachio, P, 2009-04-29 22:27:53 [InstanceEdit:419273] D'Eustachio, P, 2009-04-29 22:49:45 [InstanceEdit:500299] D'Eustachio, P, 2010-02-03 [InstanceEdit:504063] D'Eustachio, P, 2010-02-05 [InstanceEdit:504071] D'Eustachio, P, 2010-02-07 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9736313] D'Eustachio, Peter, 2021-07-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9975689] D'Eustachio, Peter, 2025-12-01
name	5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi 5-phospho-beta-D-ribosylamine + glycine + ATP => N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+) 5-phosphoribosylamine + glycine + ATP => 5-phosphoribosylglycinamide (GAR) + ADP + orthophosphate
output	[SimpleEntity:111338] PRGA [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:73815] 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate [Homo sapiens] [Reaction:111215] PRPS1 dimer pyrophosphorylates R5P using dATP [Homo sapiens] [Reaction:73580] PRPS dimers pyrophosphorylate R5P using ATP [Homo sapiens] [Reaction:111289] Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361333] R-HSA-73814.5
summation	[Summation:111339] The synthesis of cytosolic 5-phosphoribosylglycinamide from ...
(hasEvent)	[Pathway:73817] Purine ribonucleoside monophosphate biosynthesis [Homo sapiens]
(precedingEvent)	[Reaction:73813] GAR + 10-Formyl-THF => FGAR + THF [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775934] Update Tracker - [Reaction:73814] 5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi - v78:[addOutput] [_UpdateTracker:9791560] Update Tracker - [Reaction:73814] 5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi - v29:[addLiteratureReference, modifyText]
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