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Details on Person GAR + 10-Formyl-THF => FGAR + THF

Class:Id	Reaction:73813
_displayName	GAR + 10-Formyl-THF => FGAR + THF
_doRelease	TRUE
_timestamp	2025-12-01 23:58:37
authored	[InstanceEdit:111352] D'Eustachio, P, 2004-02-12 16:37:00
catalystActivity	[CatalystActivity:73808] phosphoribosylglycinamide formyltransferase activity of GART [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:73784] Jassal, B, 2003-06-26 04:06:16
edited	[InstanceEdit:165089] D'Eustachio, P, Jassal, B, 0000-00-00 00:00:00
input	[SimpleEntity:111338] PRGA [cytosol] [SimpleEntity:419151] 10-formyl-THF [cytosol]
literatureReference	[LiteratureReference:111324] De novo purine nucleotide biosynthesis: cloning of human and avian cDNAs encoding the trifunctional glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase by functional complementation in E. coli [LiteratureReference:111350] Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR [LiteratureReference:111333] Localization of GAR transformylase in Escherichia coli and mammalian cells [LiteratureReference:419266] Reversible compartmentalization of de novo purine biosynthetic complexes in living cells
modified	[InstanceEdit:74183] Jassal, B, 2003-07-17 08:31:43 [InstanceEdit:76047] D'Eustachio, P, 2003-09-22 15:47:00 [InstanceEdit:111352] D'Eustachio, P, 2004-02-12 16:37:00 [InstanceEdit:111362] D'Eustachio, P, 2004-02-12 16:43:00 [InstanceEdit:111432] D'Eustachio, P, 2004-02-13 18:28:00 [InstanceEdit:111435] D'Eustachio, P, 2004-02-14 12:33:00 [InstanceEdit:111436] D'Eustachio, P, 2004-02-14 15:35:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:419269] D'Eustachio, P, 2009-04-29 22:27:53 [InstanceEdit:419273] D'Eustachio, P, 2009-04-29 22:49:45 [InstanceEdit:500299] D'Eustachio, P, 2010-02-03 [InstanceEdit:504063] D'Eustachio, P, 2010-02-05 [InstanceEdit:504071] D'Eustachio, P, 2010-02-07 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9736313] D'Eustachio, Peter, 2021-07-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9975689] D'Eustachio, Peter, 2025-12-01
name	GAR + 10-Formyl-THF => FGAR + THF N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6R)-10-formyltetrahydrofolate => N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6S)-5,6,7,8-tetrahydrofolate + H(+) 5-phosphoribosylglycinamide (GAR) + 10-formyl-tetrahydrofolate => 5'-phosphoribosylformylglycinamide (FGAR) + tetrahydrofolate
output	[SimpleEntity:111354] N-Formyl-GAR [cytosol] [SimpleEntity:111355] THF [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:73814] 5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi [Homo sapiens] [Reaction:73815] 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:362059] R-HSA-73813.5
summation	[Summation:111361] The irreversible transfer of a formyl group to cytosolic 5-p...
(hasEvent)	[Pathway:73817] Purine ribonucleoside monophosphate biosynthesis [Homo sapiens]
(precedingEvent)	[Reaction:73812] FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775831] Update Tracker - [Reaction:73813] GAR + 10-Formyl-THF => FGAR + THF - v78:[addOutput] [_UpdateTracker:9791521] Update Tracker - [Reaction:73813] GAR + 10-Formyl-THF => FGAR + THF - v29:[addLiteratureReference, add_removeInput, modifyText]
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