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Details on Person CAIR + Aspartate + ATP => SAICAR + ADP + Pi

Class:IdReaction:73805
_displayNameCAIR + Aspartate + ATP => SAICAR + ADP + Pi
_doReleaseTRUE
_timestamp2025-12-16 18:01:25
authored[InstanceEdit:111398] D'Eustachio, P, 2004-02-13 12:25:00
catalystActivity[CatalystActivity:73801] phosphoribosylaminoimidazolesuccinocarboxamide synthase activity of PAICS octamer [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:73784] Jassal, B, 2003-06-26 04:06:16
crossReference[DatabaseIdentifier:9975687] RHEA:22629
edited[InstanceEdit:165089] D'Eustachio, P, Jassal, B, 0000-00-00 00:00:00
input[SimpleEntity:111395] CAIR [cytosol]
[SimpleEntity:29448] L-Asp [cytosol]
[SimpleEntity:113592] ATP [cytosol]
internalReviewed[InstanceEdit:9977060] D'Eustachio, Peter, 2025-12-16
literatureReference[LiteratureReference:111394] Cloning of three human multifunctional de novo purine biosynthetic genes by functional complementation of yeast mutations
[LiteratureReference:419222] Octameric structure of the human bifunctional enzyme PAICS in purine biosynthesis
[LiteratureReference:419266] Reversible compartmentalization of de novo purine biosynthetic complexes in living cells
modified[InstanceEdit:74183] Jassal, B, 2003-07-17 08:31:43
[InstanceEdit:74479] D'Eustachio, P, 2003-07-22 16:21:00
[InstanceEdit:111398] D'Eustachio, P, 2004-02-13 12:25:00
[InstanceEdit:111546] D'Eustachio, P, 2004-02-20 14:39:00
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:419269] D'Eustachio, P, 2009-04-29 22:27:53
[InstanceEdit:419273] D'Eustachio, P, 2009-04-29 22:49:45
[InstanceEdit:500299] D'Eustachio, P, 2010-02-03
[InstanceEdit:504063] D'Eustachio, P, 2010-02-05
[InstanceEdit:504071] D'Eustachio, P, 2010-02-07
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9736396] D'Eustachio, Peter, 2021-07-07
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9975689] D'Eustachio, Peter, 2025-12-01
[InstanceEdit:9977061] D'Eustachio, Peter, 2025-12-16
[InstanceEdit:9977063] D'Eustachio, Peter, 2025-12-16
nameCAIR + Aspartate + ATP => SAICAR + ADP + Pi
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP => (2S)-2-(5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido)succinate + ADP + phosphate + 2 H(+)
5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR) + L-aspartate + ATP => 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) + ADP + orthophosphate
output[SimpleEntity:111399] SAICAR [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29372] Pi [cytosol]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:70106] H+ [cytosol]
precedingEvent
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2004-07-06
reviewed[InstanceEdit:9977064] D'Eustachio, Peter, 2025-12-16
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:361349] R-HSA-73805.5
structureModified[InstanceEdit:9975689] D'Eustachio, Peter, 2025-12-01
summation[Summation:111400] The conversion of 5'-phosphoribosyl-5-aminoimidazole-4-carbo...
(hasEvent)[Pathway:73817] Purine ribonucleoside monophosphate biosynthesis [Homo sapiens]
(precedingEvent)[Reaction:73800] SAICAR => AICAR + Fumarate [Homo sapiens]
(updatedInstance)[_UpdateTracker:9775533] Update Tracker - [Reaction:73805] CAIR + Aspartate + ATP => SAICAR + ADP + Pi - v78:[addOutput]
[_UpdateTracker:9791479] Update Tracker - [Reaction:73805] CAIR + Aspartate + ATP => SAICAR + ADP + Pi - v29:[add_removeLiteratureReference, modifyText]
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