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Details on Person SAICAR => AICAR + Fumarate

Class:IdReaction:73800
_displayNameSAICAR => AICAR + Fumarate
_doReleaseTRUE
_timestamp2025-12-01 23:58:41
authored[InstanceEdit:111407] D'Eustachio, P, 2004-02-12 14:16:00
catalystActivity[CatalystActivity:73799] (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity of ADSL tetramer [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:73784] Jassal, B, 2003-06-26 04:06:16
crossReference[DatabaseIdentifier:9975678] RHEA:23921
edited[InstanceEdit:165089] D'Eustachio, P, Jassal, B, 0000-00-00 00:00:00
input[SimpleEntity:111399] SAICAR [cytosol]
literatureReference[LiteratureReference:111412] Expression, purification, and kinetic characterization of recombinant human adenylosuccinate lyase
[LiteratureReference:111414] Clinical, biochemical and molecular genetic correlations in adenylosuccinate lyase deficiency
[LiteratureReference:419266] Reversible compartmentalization of de novo purine biosynthetic complexes in living cells
modified[InstanceEdit:74183] Jassal, B, 2003-07-17 08:31:43
[InstanceEdit:111407] D'Eustachio, P, 2004-02-12 14:16:00
[InstanceEdit:111546] D'Eustachio, P, 2004-02-20 14:39:00
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:419269] D'Eustachio, P, 2009-04-29 22:27:53
[InstanceEdit:419273] D'Eustachio, P, 2009-04-29 22:49:45
[InstanceEdit:500299] D'Eustachio, P, 2010-02-03
[InstanceEdit:504063] D'Eustachio, P, 2010-02-05
[InstanceEdit:504071] D'Eustachio, P, 2010-02-07
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9975689] D'Eustachio, Peter, 2025-12-01
nameSAICAR => AICAR + Fumarate
(2S)-2-(5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido)succinate => 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate
5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + fumarate
output[SimpleEntity:111409] AICAR [cytosol]
[SimpleEntity:29586] FUMA [cytosol]
precedingEvent
releaseDate2004-07-06
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358946] R-HSA-73800.4
summation[Summation:111411] The reversible conversion of 5'-phosphoribosyl-5-aminoimidaz...
(hasEvent)[Pathway:73817] Purine ribonucleoside monophosphate biosynthesis [Homo sapiens]
(precedingEvent)[Reaction:73798] AICAR + 10-Formyl-THF => FAICAR + THF [Homo sapiens]
(updatedInstance)[_UpdateTracker:9791531] Update Tracker - [Reaction:73800] SAICAR => AICAR + Fumarate - v29:[addLiteratureReference, modifyText]
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No pathways have been reviewed or authored by SAICAR => AICAR + Fumarate (73800)
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