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Details on Person AICAR + 10-Formyl-THF => FAICAR + THF

Class:IdReaction:73798
_displayNameAICAR + 10-Formyl-THF => FAICAR + THF
_doReleaseTRUE
_timestamp2025-12-01 23:58:29
authored[InstanceEdit:111407] D'Eustachio, P, 2004-02-12 14:16:00
catalystActivity[CatalystActivity:73796] phosphoribosylaminoimidazolecarboxamide formyltransferase activity of ATIC dimer [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:73784] Jassal, B, 2003-06-26 04:06:16
crossReference[DatabaseIdentifier:9975682] RHEA:22193
edited[InstanceEdit:165089] D'Eustachio, P, Jassal, B, 0000-00-00 00:00:00
input[SimpleEntity:111409] AICAR [cytosol]
[SimpleEntity:419151] 10-formyl-THF [cytosol]
literatureReference[LiteratureReference:111425] The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
[LiteratureReference:111426] Human 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/inosine 5'-monophosphate cyclohydrolase. A bifunctional protein requiring dimerization for transformylase activity but not for cyclohydrolase activity
[LiteratureReference:419266] Reversible compartmentalization of de novo purine biosynthetic complexes in living cells
modified[InstanceEdit:74183] Jassal, B, 2003-07-17 08:31:43
[InstanceEdit:76047] D'Eustachio, P, 2003-09-22 15:47:00
[InstanceEdit:73844] 2007-03-03 09:38:00
[InstanceEdit:111431] D'Eustachio, P, 2004-02-13 18:22:00
[InstanceEdit:111435] D'Eustachio, P, 2004-02-14 12:33:00
[InstanceEdit:111436] D'Eustachio, P, 2004-02-14 15:35:00
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:419269] D'Eustachio, P, 2009-04-29 22:27:53
[InstanceEdit:419273] D'Eustachio, P, 2009-04-29 22:49:45
[InstanceEdit:500299] D'Eustachio, P, 2010-02-03
[InstanceEdit:504063] D'Eustachio, P, 2010-02-05
[InstanceEdit:504071] D'Eustachio, P, 2010-02-07
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9975689] D'Eustachio, Peter, 2025-12-01
nameAICAR + 10-Formyl-THF => FAICAR + THF
(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide => 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate
5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + 10-formyltetrahydrofolate => 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) + tetrahydrofolate
output[SimpleEntity:111427] FAICAR [cytosol]
[SimpleEntity:111355] THF [cytosol]
precedingEvent
releaseDate2004-07-06
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:361626] R-HSA-73798.4
summation[Summation:111429] The irreversible transfer of a formyl group to 5'-phosphorib...
(hasEvent)[Pathway:73817] Purine ribonucleoside monophosphate biosynthesis [Homo sapiens]
(inferredFrom)[Reaction:1113106] AICAR + 10-Formyl-THF => FAICAR + THF [Oryza sativa]
(orthologousEvent)[Reaction:1113106] AICAR + 10-Formyl-THF => FAICAR + THF [Oryza sativa]
(precedingEvent)[Reaction:73797] FAICAR => IMP + H2O [Homo sapiens]
(updatedInstance)[_UpdateTracker:9791550] Update Tracker - [Reaction:73798] AICAR + 10-Formyl-THF => FAICAR + THF - v29:[addLiteratureReference, add_removeInput, modifyText]
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No pathways have been reviewed or authored by AICAR + 10-Formyl-THF => FAICAR + THF (73798)
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