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Details on Person FAICAR => IMP + H2O

Class:Id	Reaction:73797
_displayName	FAICAR => IMP + H2O
_doRelease	TRUE
_timestamp	2025-12-01 23:58:33
authored	[InstanceEdit:73784] Jassal, B, 2003-06-26 04:06:16
catalystActivity	[CatalystActivity:73795] IMP cyclohydrolase activity of ATIC dimer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:73784] Jassal, B, 2003-06-26 04:06:16
crossReference	[DatabaseIdentifier:9975676] RHEA:18447
input	[SimpleEntity:111427] FAICAR [cytosol]
literatureReference	[LiteratureReference:111425] The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase [LiteratureReference:111426] Human 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/inosine 5'-monophosphate cyclohydrolase. A bifunctional protein requiring dimerization for transformylase activity but not for cyclohydrolase activity [LiteratureReference:419266] Reversible compartmentalization of de novo purine biosynthetic complexes in living cells
modified	[InstanceEdit:74183] Jassal, B, 2003-07-17 08:31:43 [InstanceEdit:73844] 2007-03-03 09:38:00 [InstanceEdit:111546] D'Eustachio, P, 2004-02-20 14:39:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:419269] D'Eustachio, P, 2009-04-29 22:27:53 [InstanceEdit:419273] D'Eustachio, P, 2009-04-29 22:49:45 [InstanceEdit:500299] D'Eustachio, P, 2010-02-03 [InstanceEdit:504063] D'Eustachio, P, 2010-02-05 [InstanceEdit:504071] D'Eustachio, P, 2010-02-07 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9975689] D'Eustachio, Peter, 2025-12-01
name	FAICAR => IMP + H2O 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide => IMP + H2O 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) <=> inosine 5'-monophosphate + H2O
output	[SimpleEntity:29602] IMP [cytosol] [SimpleEntity:29356] H2O [cytosol]
precedingEvent	[Reaction:73798] AICAR + 10-Formyl-THF => FAICAR + THF [Homo sapiens] [Reaction:73800] SAICAR => AICAR + Fumarate [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361978] R-HSA-73797.4
summation	[Summation:111430] The reversible synthesis of inosine 5'-monophosphate from 5'...
(hasEvent)	[Pathway:73817] Purine ribonucleoside monophosphate biosynthesis [Homo sapiens]
(inferredFrom)	[Reaction:1113193] FAICAR => IMP + H2O [Oryza sativa]
(orthologousEvent)	[Reaction:1113193] FAICAR => IMP + H2O [Oryza sativa]
(precedingEvent)	[Reaction:73794] IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] [Homo sapiens] [Reaction:74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) [Homo sapiens] [Reaction:111285] Formation of phosphoribosyl pyrophosphate amidotransferase tetramer [Homo sapiens] [Reaction:111524] IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9791492] Update Tracker - [Reaction:73797] FAICAR => IMP + H2O - v29:[addLiteratureReference, modifyText]
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No pathways have been reviewed or authored by FAICAR => IMP + H2O (73797)