Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]

Class:Id	Reaction:73794
_displayName	IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]
_doRelease	TRUE
_timestamp	2025-12-01 23:58:38
authored	[InstanceEdit:111552] D'Eustachio, P, 2004-02-23 10:40:00
catalystActivity	[CatalystActivity:73793] IMP dehydrogenase activity of IMPDH tetramers [cytosol]
catalystActivityReference	[CatalystActivityReference:9643517] IMP dehydrogenase activity of IMPDH tetramers [cytosol] Recombinant human inosine monophosphate dehydrogenase type I and type II proteins. Purification and characterization of inhibitor binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:73784] Jassal, B, 2003-06-26 04:06:16
crossReference	[DatabaseIdentifier:9975686] RHEA:11709
edited	[InstanceEdit:165080] D'Eustachio, P, 0000-00-00 00:00:00
input	[SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29602] IMP [cytosol] [SimpleEntity:29360] NAD+ [cytosol]
literatureReference	[LiteratureReference:111563] Characterization of human type I and type II IMP dehydrogenases
modified	[InstanceEdit:74183] Jassal, B, 2003-07-17 08:31:43 [InstanceEdit:74479] D'Eustachio, P, 2003-07-22 16:21:00 [InstanceEdit:76529] D'Eustachio, P, 2003-10-07 11:16:00 [InstanceEdit:76579] D'Eustachio, P, 2003-10-11 14:30:00 [InstanceEdit:111552] D'Eustachio, P, 2004-02-23 10:40:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:500265] D'Eustachio, P, 2010-02-01 [InstanceEdit:500299] D'Eustachio, P, 2010-02-03 [InstanceEdit:504063] D'Eustachio, P, 2010-02-05 [InstanceEdit:504067] D'Eustachio, P, 2010-02-05 [InstanceEdit:504071] D'Eustachio, P, 2010-02-07 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9690506] Jassal, Bijay, 2020-06-02 [InstanceEdit:9690508] Jassal, Bijay, 2020-06-02 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9975689] D'Eustachio, Peter, 2025-12-01
name	IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] IMP + NAD(+) + H2O => XMP + NADH + H(+) inosine 5'-monophosphate (IMP) + NAD+ + H2O => xanthosine 5'-monophosphate (XMP) + NADH + H+
output	[SimpleEntity:70106] H+ [cytosol] [SimpleEntity:73473] NADH [cytosol] [SimpleEntity:111584] XMP [cytosol]
precedingEvent	[Reaction:73797] FAICAR => IMP + H2O [Homo sapiens] [Reaction:73798] AICAR + 10-Formyl-THF => FAICAR + THF [Homo sapiens]
regulatedBy	[NegativeRegulation:111589] Negative regulation by 'XMP [cytosol]' [NegativeRegulation:9690505] Negative regulation by 'IMPDH tetramers:IMPDH inhibitors [cytosol]'
regulationReference	[RegulationReference:9690507] Negative regulation by 'IMPDH tetramers:IMPDH inhibitors [cytosol]' Synthesis and immunosuppressive activity of some side-chain variants of mycophenolic acid
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359055] R-HSA-73794.7
summation	[Summation:111588] Two human isoenzymes, IMP dehydrogenase 1 and 2 (IMPDH1,2) c...
(hasEvent)	[Pathway:73817] Purine ribonucleoside monophosphate biosynthesis [Homo sapiens]
(inferredFrom)	[Reaction:421222] inosine 5'-monophosphate (IMP) + NAD+ + H2O => xanthosine 5'-monophosphate (XMP) + NADH + H+ [Gallus gallus] [Reaction:1113151] IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] [Oryza sativa]
(orthologousEvent)	[Reaction:1113151] IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] [Oryza sativa]
(precedingEvent)	[Reaction:73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate [Homo sapiens]
(replacementInstances)	[_Deleted:500313] Deletion of instance: 111593
(updatedInstance)	[_UpdateTracker:9776862] Update Tracker - [Reaction:73794] IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] - v74:[addRegulator] [_UpdateTracker:9791137] Update Tracker - [Reaction:73794] IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] - v32:[add_removeSummation] [_UpdateTracker:9984711] Update Tracker - [Reaction:73794] IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] - v96:[modifyText]
[Change default viewing format]

No pathways have been reviewed or authored by IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (73794)