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Details on Person XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate

Class:IdReaction:73792
_displayNameXMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate
_doReleaseTRUE
_timestamp2025-12-01 23:58:42
authored[InstanceEdit:111600] D'Eustachio, P, 2004-02-23 15:33:00
catalystActivity[CatalystActivity:73785] GMP synthase (glutamine-hydrolyzing) activity of GMPS [cytosol]
catalystActivityReference[CatalystActivityReference:9643930] GMP synthase (glutamine-hydrolyzing) activity of GMPS [cytosol] Biochemical characterization of human GMP synthetase
compartment[Compartment:70101] cytosol
created[InstanceEdit:73784] Jassal, B, 2003-06-26 04:06:16
crossReference[DatabaseIdentifier:9975680] RHEA:11681
edited[InstanceEdit:165089] D'Eustachio, P, Jassal, B, 0000-00-00 00:00:00
input[SimpleEntity:111584] XMP [cytosol]
[SimpleEntity:29472] L-Gln [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:29356] H2O [cytosol]
literatureReference[LiteratureReference:111603] Human GMP synthetase. Protein purification, cloning, and functional expression of cDNA
[LiteratureReference:111608] Biochemical characterization of human GMP synthetase
modified[InstanceEdit:74183] Jassal, B, 2003-07-17 08:31:43
[InstanceEdit:74479] D'Eustachio, P, 2003-07-22 16:21:00
[InstanceEdit:111552] D'Eustachio, P, 2004-02-23 10:40:00
[InstanceEdit:111600] D'Eustachio, P, 2004-02-23 15:33:00
[InstanceEdit:143510] D'Eustachio, P, 2004-11-11 21:39:46
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:500299] D'Eustachio, P, 2010-02-03
[InstanceEdit:504063] D'Eustachio, P, 2010-02-05
[InstanceEdit:504071] D'Eustachio, P, 2010-02-07
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9736400] D'Eustachio, Peter, 2021-07-08
[InstanceEdit:9748647] D'Eustachio, Peter, 2021-07-23
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9975689] D'Eustachio, Peter, 2025-12-01
nameXMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate
xanthosine 5'-monophosphate (XMP) + L-glutamine + ATP + H2O => guanosine 5'-monophosphate (GMP) + L-glutamate + adenosine 5'-monophosphate (AMP) + pyrophosphate
XMP + L-glutamine + ATP + H2O => GMP + L-glutamate + AMP + diphosphate + 2 H(+)
output[SimpleEntity:113578] GMP [cytosol]
[SimpleEntity:29404] L-Glu [cytosol]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:76577] AMP [cytosol]
[SimpleEntity:111294] PPi [cytosol]
precedingEvent
releaseDate2004-07-06
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:360816] R-HSA-73792.6
summation[Summation:111610] Cytosolic GMP synthase (GMPS) catalyzes the reaction of xant...
(hasEvent)[Pathway:73817] Purine ribonucleoside monophosphate biosynthesis [Homo sapiens]
(inferredFrom)[Reaction:421218] xanthosine 5'-monophosphate (XMP) + L-glutamine + ATP + H2O => guanosine 5'-monophosphate (GMP) + L-glutamate + adenosine 5'-monophosphate (AMP) + pyrophosphate [Gallus gallus]
[Reaction:1113131] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate [Oryza sativa]
(orthologousEvent)[Reaction:1113131] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate [Oryza sativa]
(precedingEvent)[Reaction:71732] PPA1 hydrolyzes pyrophosphate to orthophosphate [Homo sapiens]
[Reaction:73788] (d)GMP + ATP <=> (d)GDP + ADP (GUK1) [Homo sapiens]
[Reaction:74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) [Homo sapiens]
[Reaction:111285] Formation of phosphoribosyl pyrophosphate amidotransferase tetramer [Homo sapiens]
(updatedInstance)[_UpdateTracker:9776060] Update Tracker - [Reaction:73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - v78:[addOutput]
[_UpdateTracker:9790957] Update Tracker - [Reaction:73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - v32:[modifyText]
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No pathways have been reviewed or authored by XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate (73792)
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