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Details on Person (d)GMP + ATP <=> (d)GDP + ADP (GUK1)

Class:Id	Reaction:73788
_displayName	(d)GMP + ATP <=> (d)GDP + ADP (GUK1)
_doRelease	TRUE
_timestamp	2025-12-04 01:21:32
catalystActivity	[CatalystActivity:74189] GMP kinase activity of GUK1 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643996] guanylate kinase activity of GUK1 [cytosol] Cloning, characterization, and modeling of mouse and human guanylate kinases
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:73784] Jassal, B, 2003-06-26 04:06:16
crossReference	[DatabaseIdentifier:9975902] RHEA:20781 [DatabaseIdentifier:9975909] RHEA:12698
input	[DefinedSet:500071] (d)GMP [cytosol] [SimpleEntity:113592] ATP [cytosol]
literatureReference	[LiteratureReference:110117] Guanylate kinases from human erythrocytes, hog brain, and rat liver [LiteratureReference:500070] Cloning, characterization, and modeling of mouse and human guanylate kinases [LiteratureReference:110100] Studies on the properties and tissue distribution of the isozymes of guanylate kinase in man [LiteratureReference:110121] Phosphorylation of acyclovir (acycloguanosine) monophosphate by GMP kinase
modified	[InstanceEdit:74183] Jassal, B, 2003-07-17 08:31:43 [InstanceEdit:74479] D'Eustachio, P, 2003-07-22 16:21:00 [InstanceEdit:110076] D'Eustachio, P, 2004-01-28 17:55:00 [InstanceEdit:110253] D'Eustachio, P, 0000-00-00 00:00:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:499929] D'Eustachio, P, 2010-01-29 [InstanceEdit:500076] D'Eustachio, P, 2010-01-30 [InstanceEdit:504063] D'Eustachio, P, 2010-02-05 [InstanceEdit:504071] D'Eustachio, P, 2010-02-07 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8956390] D'Eustachio, Peter, 2017-01-22 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9975916] D'Eustachio, Peter, 2025-12-04
name	(d)GMP + ATP <=> (d)GDP + ADP (GUK1) GMP + ATP => GDP + ADP dGMP + ATP => dGDP + ADP
output	[DefinedSet:500077] (d)GDP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate [Homo sapiens] [Reaction:73794] IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] [Homo sapiens] [Reaction:74207] dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK) [Homo sapiens]
releaseDate	2004-07-06
reverseReaction	[Reaction:110133] (d)GDP + ADP <=> (d)GMP + ATP (GUK1) [Homo sapiens] [Reaction:73788] (d)GMP + ATP <=> (d)GDP + ADP (GUK1) [Homo sapiens]
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359080] R-HSA-73788.7
summation	[Summation:499941] Cytosolic guanylate kinase 1 (GUK1) catalyzes the reversible...
(hasEvent)	[Pathway:499943] Interconversion of nucleotide di- and triphosphates [Homo sapiens]
(precedingEvent)	[Reaction:482619] (d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) [Homo sapiens]
(replacementInstances)	[_Deleted:500081] Deletion of instance: 110116 [_Deleted:500082] Deletion of instance: 74204
(reverseReaction)	[Reaction:110133] (d)GDP + ADP <=> (d)GMP + ATP (GUK1) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790992] Update Tracker - [Reaction:73788] (d)GMP + ATP <=> (d)GDP + ADP (GUK1) - v32:[addLiteratureReference, add_removeInput, add_removeOutput, add_removeSummation]
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