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Details on Person Upon transcription initiation it is thought that RRN3 is ina...
| Class:Id | Summation:73771 |
|---|---|
| _displayName | Upon transcription initiation it is thought that RRN3 is ina... |
| _timestamp | 2026-05-06 18:58:00 |
| created | [InstanceEdit:73851] Comai, L, 2003-07-03 17:13:29 |
| modified | [InstanceEdit:73849] Gillespie, ME, 2003-07-01 00:00:00 [InstanceEdit:74972] Gillespie, ME, 2003-07-30 00:00:00 [InstanceEdit:141448] Matthews, L, 2004-09-20 15:43:00 [InstanceEdit:9988348] Rothfels, Karen, 2026-05-06 |
| text | Upon transcription initiation it is thought that RRN3 is inactivated and dissociates from the initiation complex (Hirschler-Laszkiewicz et al, 2003; Sadian et al, 2019). SL1 and UBF are thought to remain bound to the promoter for multiple rounds of transcription initiation (Panov et al, 2001). Unlike RNA Pol II, RNA Pol I does not require ATP hydrolysis to open DNA and initiate transcription (Iben et al, 2002; reviewed in Girbig et al, 2022). Opening of the promoter is accompanied by a conformational change involving the RNA Pol I clamp, resulting in tighter DNA binding and release of RRN3 (Misiaszek et al, 2021; Sadian et al, 2017; Engel et al, 2017; Han et al, 2017; Sadian et al, 2019; Plisl et al, 2020). |
| (summation) | [Reaction:73769] Loss of RRN3 from RNA Polymerase I promoter escape complex [Homo sapiens] |
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No pathways have been reviewed or authored by Upon transcription initiation it is thought that RRN3 is ina... (73771)
