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Details on Person Loss of RRN3 from RNA Polymerase I promoter escape complex

Class:Id	Reaction:73769
_displayName	Loss of RRN3 from RNA Polymerase I promoter escape complex
_doRelease	TRUE
_timestamp	2026-05-06 19:06:09
authored	[InstanceEdit:73851] Comai, L, 2003-07-03 17:13:29
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:73851] Comai, L, 2003-07-03 17:13:29
edited	[InstanceEdit:165085] Gillespie, ME, 0000-00-00 00:00:00
input	[Complex:73716] RNA Polymerase I transcription initiation complex:45S pre-rRNA gene [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:73770] Rrn3 becomes inactivated in the process of ribosomal DNA transcription. [LiteratureReference:9987948] Molecular insight into RNA polymerase I promoter recognition and promoter melting [LiteratureReference:9987942] A step subsequent to preinitiation complex assembly at the ribosomal RNA gene promoter is rate limiting for human RNA polymerase I-dependent transcription [LiteratureReference:9988024] TFIIH plays an essential role in RNA polymerase I transcription [LiteratureReference:9987995] Structural insights into nuclear transcription by eukaryotic DNA-dependent RNA polymerases [LiteratureReference:9987996] Structural insights into transcription initiation by yeast RNA polymerase I [LiteratureReference:9987989] Structural Basis of RNA Polymerase I Transcription Initiation [LiteratureReference:9988002] Structural mechanism of ATP-independent transcription initiation by RNA polymerase I [LiteratureReference:9987992] Structural basis of RNA polymerase I pre-initiation complex formation and promoter melting
modified	[InstanceEdit:73849] Gillespie, ME, 2003-07-01 00:00:00 [InstanceEdit:74972] Gillespie, ME, 2003-07-30 00:00:00 [InstanceEdit:156966] Gillespie, ME, 2004-12-14 22:05:31 [InstanceEdit:156971] Gillespie, ME, 2004-12-14 22:14:44 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:5419295] May, Bruce, 2014-05-04 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9988367] Rothfels, Karen, 2026-05-06
name	Loss of RRN3 from RNA Polymerase I promoter escape complex
output	[Complex:73717] RNA Polymerase I promoter escape complex:45S pre-rRNA gene [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:73714] RRN3 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:73758] Recruitment of RNA Polymerase I:RRN3 to the 45S pre-rRNA gene [Homo sapiens] [Reaction:73757] Binding of RRN3 to RNA Polymerase I [Homo sapiens] [Reaction:73739] Recruitment of acetylated SL1 to p-UBTF:45S pre-rRNA gene [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361354] R-HSA-73769.3
summation	[Summation:73771] Upon transcription initiation it is thought that RRN3 is ina...
(hasEvent)	[Pathway:73772] RNA Polymerase I Promoter Escape [Homo sapiens]
(inferredFrom)	[Reaction:1113256] Loss of Rrn3 from RNA Polymerase I promoter escape complex [Oryza sativa]
(orthologousEvent)	[Reaction:1113256] Loss of Rrn3 from RNA Polymerase I promoter escape complex [Oryza sativa]
(precedingEvent)	[Reaction:74986] Elongation of pre-rRNA transcript [Homo sapiens]
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