Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person Human SL1 does not bind to DNA itself, rather it is recruite...
| Class:Id | Summation:73746 |
|---|---|
| _displayName | Human SL1 does not bind to DNA itself, rather it is recruite... |
| _timestamp | 2003-11-17 20:06:10 |
| created | [InstanceEdit:73851] Comai, L, 2003-07-03 17:13:29 |
| literatureReference | [LiteratureReference:75839] Rb and p130 regulate RNA polymerase I transcription: Rb disrupts the interaction between UBF and SL-1. [LiteratureReference:73744] Repression of RNA polymerase I transcription by the tumor suppressor p53. [LiteratureReference:75840] Overlapping functions of the pRb family in the regulation of rRNA synthesis. |
| modified | [InstanceEdit:73849] Gillespie, ME, 2003-07-01 00:00:00 [InstanceEdit:75829] Gillespie, ME, 2003-09-02 00:00:00 [InstanceEdit:83531] Gillespie, ME, 2003-11-13 00:00:00 |
| text | Human SL1 does not bind to DNA itself, rather it is recruited to the rDNA promoter through a physical interaction with UBF-1. Phosphorylation of UBF-1 within the carboxy-terminal region is required for SL1 binding. SL1 consists of TATA-binding protein (TBP) and three associated factors (TAFIs). SL1 has no sequence-specific DNA binding activity its recruitment to the promoter being mediated by specific interactions with UBF. Once bound the SL1 complex makes direct contact with the DNA promoter and guides promoter-specific initiation. Studies to identify the mechanistic relationship between SL1 and UBF-1 have indicated that the interaction between UBF-1 and SL1 is regulated by tumor suppressor proteins such as Rb and P53, although it has also been proposed that Rb prevents UBF-1 from binding to DNA itself. |
| (summation) | [Reaction:73739] Recruitment of acetylated SL1 to p-UBTF:45S pre-rRNA gene [Homo sapiens] |
| [Change default viewing format] | |
