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Query author contributions in Reactome

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Details on Person UBTF binds rDNA Promoter

Class:IdReaction:73718
_displayNameUBTF binds rDNA Promoter
_doReleaseTRUE
_timestamp2026-05-14 20:18:02
authored[InstanceEdit:73851] Comai, L, 2003-07-03 17:13:29
compartment[Compartment:350] nucleolus
created[InstanceEdit:73851] Comai, L, 2003-07-03 17:13:29
edited[InstanceEdit:165085] Gillespie, ME, 0000-00-00 00:00:00
figure[Figure:75838] /figures/PolI_txn_UBF_rDNA.jpg
input[EntityWithAccessionedSequence:73683] UBTF [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:9987889] 45S pre-rRNA gene [nucleoplasm] [Homo sapiens]
internalReviewed[InstanceEdit:9989056] Gillespie, Marc E, 2026-05-14
literatureReference[LiteratureReference:73719] Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins.
modified[InstanceEdit:73849] Gillespie, ME, 2003-07-01 00:00:00
[InstanceEdit:75829] Gillespie, ME, 2003-09-02 00:00:00
[InstanceEdit:83531] Gillespie, ME, 2003-11-13 00:00:00
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9641190] Wu, G, 2019-04-04
[InstanceEdit:9733355] Wu, Guanming, 2021-06-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9988367] Rothfels, Karen, 2026-05-06
[InstanceEdit:9989078] Rothfels, Karen, 2026-05-14
nameUBTF binds rDNA Promoter
output[Complex:9988363] UBTF:45S pre-rRNA gene [nucleoplasm] [Homo sapiens]
previousReviewStatus[ReviewStatus:9821384] two stars
regulatedBy[NegativeRegulation:427398] Negative regulation by 'Chromatin (H3K9me2, 5mC):MBD2 [nucleoplasm]'
regulationReference[RegulationReference:9642677] Negative regulation by 'Chromatin (H3K9me2, 5mC):MBD2 [nucleoplasm]' Molecular mechanisms mediating methylation-dependent silencing of ribosomal gene transcription
releaseDate2004-07-06
reviewStatus[ReviewStatus:9821385] four stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:361858] R-HSA-73718.6
structureModified[InstanceEdit:9988367] Rothfels, Karen, 2026-05-06
summation[Summation:73721] UBF-1 binds directly to the CORE and UCE elements of the rib...
[Summation:427326] Methylcytosine in the promoter of a rRNA gene binds MBD2 (an...
(hasEvent)[Pathway:73728] RNA Polymerase I Promoter Opening [Homo sapiens]
(precedingEvent)[Reaction:73722] Phosphorylation of UBTF [Homo sapiens]
(updatedInstance)[_UpdateTracker:9776045] Update Tracker - [Reaction:73718] UBF-1 Binds rDNA Promoter - v78:[addSummation]
[_UpdateTracker:9791418] Update Tracker - [Reaction:73718] UBF-1 Binds rDNA Promoter - v30:[addRegulator]
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