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Details on Person UniProt:Q791N7 Polr1h
| Class:Id | ReferenceGeneProduct:73695 |
|---|---|
| _chainChangeLog | chain:1-123 added on Fri February 6 2015 |
| _displayName | UniProt:Q791N7 Polr1h |
| _timestamp | 2024-08-09 18:37:33 |
| chain | chain:1-123 |
| checksum | 23F3407757502D61 |
| comment | FUNCTION Core component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Can mediate Pol I proofreading of the nascent RNA transcript. Anchors into the Pol I active site to monitor transcription fidelity and cleave mis-incorporated 5'-ribonucleotides.SUBUNIT Component of the RNA polymerase I (Pol I) complex consisting of 13 subunits: a ten-subunit catalytic core composed of POLR1A/RPA1, POLR1B/RPA2, POLR1C/RPAC1, POLR1D/RPAC2, POLR1H/RPA12, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk subunit POLR1F/RPA43 protruding from the core and additional subunits homologous to general transcription factors POLR1E/RPA49 and POLR1G/RPA34. Part of Pol I pre-initiation complex (PIC), in which Pol I core assembles with RRN3 and promoter-bound UTBF and SL1/TIF-IB complex.SUBCELLULAR LOCATION The TFIIS-type zinc-binding beta-ribbon domain contains an acidic hairpin motif (residues Asp-103, Glu-104) that likely coordinates the nucleophilic water and magnesium to cleave the scissile phosphodiester bond and release the mis-incorporated 5'-ribonucleotides.SIMILARITY Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. |
| description | recommendedName: fullName evidence="7"DNA-directed RNA polymerase I subunit RPA12 alternativeName: fullName evidence="1"DNA-directed RNA polymerase I subunit H alternativeName: fullName evidence="8"Zinc ribbon domain-containing protein 1 |
| geneName | Polr1h Rpa12 Znrd1 |
| identifier | Q791N7 |
| isSequenceChanged | FALSE |
| keyword | DNA-directed RNA polymerase Metal-binding Nucleus Reference proteome Transcription Zinc Zinc-finger |
| modified | [InstanceEdit:73862] Gillespie, ME, 2003-07-03 00:00:00 [InstanceEdit:142030] Schmidt, EE, 2004-10-27 09:38:11 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9698430] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 |
| name | Polr1h |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | RPA12_MOUSE |
| sequenceLength | 123 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:73696] p12 [nucleoplasm] [Mus musculus] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q791N7 Polr1h (73695)
