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Details on Person UniProt:Q15573 TAF1A
| Class:Id | ReferenceGeneProduct:73688 |
|---|---|
| _chainChangeLog | chain:1-450 added on Sat February 7 2015 |
| _displayName | UniProt:Q15573 TAF1A |
| _timestamp | 2024-11-03 20:21:46 |
| chain | chain:1-450 |
| checksum | 130330D78493C4D8 |
| comment | FUNCTION Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.SUBUNIT Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits. Interacts with UBFT. Interacts with CEBPA (isoform 1 and isoform 4) (PubMed:20075868). Part of Pol I pre-initiation complex (PIC), in which Pol I core assembles with RRN3 and promoter-bound UTBF and SL1/TIF-IB complex. |
| created | [InstanceEdit:73680] Gillespie, ME, 0000-00-00 00:00:00 |
| description | recommendedName: TATA box-binding protein-associated factor RNA polymerase I subunit A alternativeName: RNA polymerase I-specific TBP-associated factor 48 kDa shortName: TAFI48 alternativeName: TATA box-binding protein-associated factor 1A shortName: TBP-associated factor 1A alternativeName: Transcription factor SL1 alternativeName: Transcription initiation factor SL1/TIF-IB subunit A |
| geneName | TAF1A |
| identifier | Q15573 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Direct protein sequencing DNA-binding Nucleus Proteomics identification Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | TAF1A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988143] ENSEMBL:ENSG00000143498 TAF1A [Homo sapiens] |
| secondaryIdentifier | TAF1A_HUMAN B2RDZ8 D3DTB7 Q9NWA1 |
| sequenceLength | 450 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:250381] UniProt:Q15573-2 TAF1A [Homo sapiens] [ReferenceIsoform:405866] UniProt:Q15573-1 TAF1A [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:73689] TAF1A [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q15573 TAF1A (73688)
