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Details on Person UniProt:Q15572 TAF1C
| Class:Id | ReferenceGeneProduct:73686 |
|---|---|
| _chainChangeLog | chain:1-869 added on Sat February 7 2015 |
| _displayName | UniProt:Q15572 TAF1C |
| _timestamp | 2024-11-03 19:54:15 |
| chain | chain:1-869 |
| checksum | 6AAFAF296D98A5DB |
| comment | FUNCTION Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3.SUBUNIT Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits. Interacts with MYC and RRN3. Interacts with p53/TP53; the interaction prevents the association of SL1/TIF-IB with UBTF and represses RNA polymerase I transcription. Part of Pol I pre-initiation complex (PIC), in which Pol I core assembles with RRN3 and promoter-bound UTBF and SL1/TIF-IB complex.INTERACTION Probable cloning artifact. |
| created | [InstanceEdit:73680] Gillespie, ME, 0000-00-00 00:00:00 |
| description | recommendedName: TATA box-binding protein-associated factor RNA polymerase I subunit C alternativeName: RNA polymerase I-specific TBP-associated factor 110 kDa shortName: TAFI110 alternativeName: TATA box-binding protein-associated factor 1C shortName: TBP-associated factor 1C alternativeName: Transcription initiation factor SL1/TIF-IB subunit C |
| geneName | TAF1C |
| identifier | Q15572 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Direct protein sequencing DNA-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | TAF1C |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001477] ENSEMBL:ENSG00000103168 TAF1C [Homo sapiens] |
| secondaryIdentifier | TAF1C_HUMAN B7Z5K5 B7Z5S4 B7Z908 B7Z9L7 Q59F67 Q8N6V3 |
| sequenceLength | 869 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:250387] UniProt:Q15572-2 TAF1C [Homo sapiens] [ReferenceIsoform:405865] UniProt:Q15572-1 TAF1C [Homo sapiens] [ReferenceIsoform:8973521] UniProt:Q15572-4 TAF1C [Homo sapiens] [ReferenceIsoform:8973522] UniProt:Q15572-5 TAF1C [Homo sapiens] [ReferenceIsoform:8973523] UniProt:Q15572-6 TAF1C [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:73687] TAF1C [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q15572 TAF1C (73686)
