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Details on Person Amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTPS)

Class:IdReaction:73647
_displayNameAmination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTPS)
_doReleaseTRUE
_timestamp2025-12-16 18:01:22
catalystActivity[CatalystActivity:73537] CTP synthase activity of CTPS tetramer [cytosol]
catalystActivityReference[CatalystActivityReference:9643175] CTP synthase activity of CTPS tetramer [cytosol] Expression of Human CTP synthetase in Saccharomyces cerevisiae reveals phosphorylation by protein kinase A
compartment[Compartment:70101] cytosol
created[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
crossReference[DatabaseIdentifier:9975911] RHEA:26427
input[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:29356] H2O [cytosol]
[SimpleEntity:29472] L-Gln [cytosol]
[SimpleEntity:29494] UTP [cytosol]
internalReviewed[InstanceEdit:9977060] D'Eustachio, Peter, 2025-12-16
literatureReference[LiteratureReference:200249] Expression of Human CTP synthetase in Saccharomyces cerevisiae reveals phosphorylation by protein kinase A
[LiteratureReference:504059] Structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy
modified[InstanceEdit:74394] D'Eustachio, P, 2003-07-21 13:51:00
[InstanceEdit:74479] D'Eustachio, P, 2003-07-22 16:21:00
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:200252] D'Eustachio, P, 2007-07-16 20:10:20
[InstanceEdit:351722] D'Eustachio, P, 2008-05-27 19:58:18
[InstanceEdit:351725] D'Eustachio, P, 2008-05-27 20:02:47
[InstanceEdit:482759] D'Eustachio, P, 2010-01-28
[InstanceEdit:504056] D'Eustachio, P, 2010-02-05
[InstanceEdit:504063] D'Eustachio, P, 2010-02-05
[InstanceEdit:504071] D'Eustachio, P, 2010-02-07
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9737139] D'Eustachio, Peter, 2021-07-16
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9975916] D'Eustachio, Peter, 2025-12-04
[InstanceEdit:9977061] D'Eustachio, Peter, 2025-12-16
[InstanceEdit:9977063] D'Eustachio, Peter, 2025-12-16
nameAmination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTPS)
UTP + L-glutamine + ATP + H2O => CTP + L-glutamate + ADP + phosphate + 2 H(+)
output[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:110614] CTP [cytosol]
[SimpleEntity:29404] L-Glu [cytosol]
[SimpleEntity:29372] Pi [cytosol]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:70106] H+ [cytosol]
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2004-07-06
reviewed[InstanceEdit:9977064] D'Eustachio, Peter, 2025-12-16
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:360008] R-HSA-73647.6
structureModified[InstanceEdit:9975916] D'Eustachio, Peter, 2025-12-04
summation[Summation:179322] Cytosolic CTP synthase 1 (CTPS) catalyzes the reaction of UT...
(hasEvent)[Pathway:499943] Interconversion of nucleotide di- and triphosphates [Homo sapiens]
(precedingEvent)[Reaction:482621] (d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) [Homo sapiens]
(updatedInstance)[_UpdateTracker:9775860] Update Tracker - [Reaction:73647] UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] - v78:[addOutput]
[_UpdateTracker:9790858] Update Tracker - [Reaction:73647] UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] - v32:[addLiteratureReference, modifyText]
[_UpdateTracker:9791879] Update Tracker - [Reaction:73647] UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] - v25:[add_removeInput, add_removeOutput]
[_UpdateTracker:9792378] Update Tracker - [Reaction:73647] UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] - v22:[addLiteratureReference]
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