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Details on Person Regeneration of active (reduced) Thioredoxin

Class:IdReaction:73646
_displayNameRegeneration of active (reduced) Thioredoxin
_doReleaseTRUE
_timestamp2025-12-04 01:21:43
authored[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
catalystActivity[CatalystActivity:73533] thioredoxin-disulfide reductase (NADPH) activity of TNXRD1:FAD dimer [cytosol]
catalystActivityReference[CatalystActivityReference:9643312] thioredoxin-disulfide reductase activity of TNXRD1:FAD dimer [cytosol] Truncated mutants of human thioredoxin reductase 1 do not exhibit glutathione reductase activity
compartment[Compartment:70101] cytosol
created[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
crossReference[DatabaseIdentifier:9975914] RHEA:20347
edited[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
input[EntityWithAccessionedSequence:73668] 2xHC-TXN [cytosol] [Homo sapiens]
[SimpleEntity:29364] NADPH [cytosol]
[SimpleEntity:70106] H+ [cytosol]
literatureReference[LiteratureReference:200264] Truncated mutants of human thioredoxin reductase 1 do not exhibit glutathione reductase activity
modified[InstanceEdit:74183] Jassal, B, 2003-07-17 08:31:43
[InstanceEdit:74394] D'Eustachio, P, 2003-07-21 13:51:00
[InstanceEdit:111698] D'Eustachio, P, 2004-03-17 17:27:00
[InstanceEdit:111773] D'Eustachio, P, 2004-04-03 16:52:00
[InstanceEdit:111817] D'Eustachio, P, 2004-03-19 16:11:00
[InstanceEdit:143503] D'Eustachio, P, 2004-11-11 20:38:39
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:164829] D'Eustachio, P, 2005-06-28 20:49:38
[InstanceEdit:200252] D'Eustachio, P, 2007-07-16 20:10:20
[InstanceEdit:499929] D'Eustachio, P, 2010-01-29
[InstanceEdit:504063] D'Eustachio, P, 2010-02-05
[InstanceEdit:504071] D'Eustachio, P, 2010-02-07
[InstanceEdit:3343748] May, B, 2013-05-12
[InstanceEdit:8855986] Orlic-Milacic, Marija, 2016-02-08
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9975916] D'Eustachio, Peter, 2025-12-04
nameRegeneration of active (reduced) Thioredoxin
(thioredoxin)-disulfide + NADPH + H(+) => (thioredoxin)-dithiol + NADP(+)
output[EntityWithAccessionedSequence:66000] TXN [cytosol] [Homo sapiens]
[SimpleEntity:29366] NADP+ [cytosol]
releaseDate2004-07-06
releaseStatusUPDATED
reviewed[InstanceEdit:8855680] Inga, Alberto, 2016-02-04
[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:360826] R-HSA-73646.6
summation[Summation:499946] Cytosolic thioredoxin reductase catalyzes the reaction of th...
(hasEvent)[Pathway:499943] Interconversion of nucleotide di- and triphosphates [Homo sapiens]
[Pathway:3299685] Detoxification of Reactive Oxygen Species [Homo sapiens]
[Pathway:5628897] TP53 Regulates Metabolic Genes [Homo sapiens]
(precedingEvent)[Reaction:111751] RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) [Homo sapiens]
[Reaction:111804] RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) [Homo sapiens]
[Reaction:3341343] PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O [Homo sapiens]
[Reaction:3697882] PRDX5 reduces peroxynitrite to nitrite using TXN [Homo sapiens]
[Reaction:5631885] PRDX1 overoxidizes [Homo sapiens]
(replacementInstances)[_Deleted:8866417] Deletion of instance: 111806
(updatedInstance)[_UpdateTracker:9791229] Update Tracker - [Reaction:73646] thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ - v32:[add_removeSummation]
[_UpdateTracker:9792388] Update Tracker - [Reaction:73646] thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ - v22:[addLiteratureReference]
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