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Details on Person RNR (M1M2) [cytosol]

Class:Id	Complex:73640
_displayName	RNR (M1M2) [cytosol]
_timestamp	2016-03-31 19:52:13
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
goCellularComponent	[GO_CellularComponent:19477] ribonucleoside-diphosphate reductase complex
hasComponent	[Complex:111735] RRM1 dimer [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:73638] RRM1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:73638] RRM1 [cytosol] [Homo sapiens] [Complex:111737] RRM2 dimer [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:73639] RRM2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:73639] RRM2 [cytosol] [Homo sapiens] [SimpleEntity:111736] Fe3+ [cytosol] [SimpleEntity:111736] Fe3+ [cytosol]
literatureReference	[LiteratureReference:499990] A dityrosyl-diiron radical cofactor center is essential for human ribonucleotide reductases [LiteratureReference:8866393] Ribonucleotide reduction is a cytosolic process in mammalian cells independently of DNA damage
modified	[InstanceEdit:111698] D'Eustachio, P, 2004-03-17 17:27:00 [InstanceEdit:499992] D'Eustachio, P, 2010-01-29 [InstanceEdit:2173605] D'Eustachio, P, 2012-03-30 [InstanceEdit:8866392] D'Eustachio, Peter, 2016-03-31 [InstanceEdit:8866407] D'Eustachio, Peter, 2016-03-31 [InstanceEdit:9658105] Weiser, JD, 2019-08-09 [InstanceEdit:9658105] Weiser, JD, 2019-08-09 [InstanceEdit:9666277] Weiser, JD, 2019-11-04 [InstanceEdit:9666277] Weiser, JD, 2019-11-04 [InstanceEdit:9676538] Cook, Justin, 2020-02-17 [InstanceEdit:9676538] Cook, Justin, 2020-02-17 [InstanceEdit:9689079] Cook, Justin, 2020-05-15 [InstanceEdit:9689079] Cook, Justin, 2020-05-15 [InstanceEdit:9715688] Shorser, Solomon, 2021-02-17 [InstanceEdit:9729976] Shorser, Solomon, 2021-05-05 [InstanceEdit:9750461] Weiser, JD, 2021-08-11 [InstanceEdit:9757984] Weiser, JD, 2021-11-08 [InstanceEdit:9767390] Wright, Adam, 2022-02-25 [InstanceEdit:9773515] Weiser, Joel, 2022-05-04 [InstanceEdit:9909910] Weiser, Joel, 2024-05-14 [InstanceEdit:9917728] Weiser, Joel, 2024-08-09 [InstanceEdit:9926726] Weiser, Joel, 2024-11-03 [InstanceEdit:9939161] Weiser, Joel, 2025-02-21 [InstanceEdit:9948552] Weiser, Joel, 2025-05-21 [InstanceEdit:9963749] Weiser, Joel, 2025-08-15 [InstanceEdit:9970792] Weiser, Joel, 2025-10-31 [InstanceEdit:9983308] Weiser, Joel, 2026-02-22 [InstanceEdit:9989150] Weiser, Joel, 2026-05-15
name	RNR (M1M2) ribonucleotide reductase ribonucleosidePP reductase
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:370683] R-HSA-73640.20
(physicalEntity)	[CatalystActivity:73641] ribonucleoside-diphosphate reductase activity, glutaredoxin disulfide as acceptor of RNR (M1M2) [cytosol] [CatalystActivity:8866404] ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor of RNR (M1M2) [cytosol]
(updatedInstance)	[_UpdateTracker:9868653] Update Tracker - [Complex:73640] RNR (M1M2) [cytosol] - v32:[addLiteratureReference] [_UpdateTracker:9894443] Update Tracker - [Complex:73640] RNR (M1M2) [cytosol] - v57:[addLiteratureReference, addName, updateContainedComponent]
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No pathways have been reviewed or authored by RNR (M1M2) [cytosol] (73640)