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Details on Person dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK]

Class:Id	Reaction:73635
_displayName	dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK]
_doRelease	TRUE
_timestamp	2025-12-04 01:21:45
catalystActivity	[CatalystActivity:73499] nucleoside monophosphate kinase activity of DTYMK dimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9644065] nucleoside monophosphate kinase activity of DTYMK dimer [cytosol] Human thymidylate kinase. Purification, characterization, and kinetic behavior of the thymidylate kinase derived from chronic myelocytic leukemia
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
crossReference	[DatabaseIdentifier:9975915] RHEA:30656 [DatabaseIdentifier:9975901] RHEA:13518
input	[DefinedSet:499997] dUMP, TMP [cytosol] [SimpleEntity:113592] ATP [cytosol]
literatureReference	[LiteratureReference:110105] Human thymidylate kinase. Purification, characterization, and kinetic behavior of the thymidylate kinase derived from chronic myelocytic leukemia
modified	[InstanceEdit:74394] D'Eustachio, P, 2003-07-21 13:51:00 [InstanceEdit:74479] D'Eustachio, P, 2003-07-22 16:21:00 [InstanceEdit:75119] D'Eustachio, P, 2003-08-25 12:00:00 [InstanceEdit:110076] D'Eustachio, P, 2004-01-28 17:55:00 [InstanceEdit:110253] D'Eustachio, P, 0000-00-00 00:00:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:166447] Jassal, B, 2005-09-07 11:02:57 [InstanceEdit:499998] D'Eustachio, P, 2010-01-29 [InstanceEdit:504063] D'Eustachio, P, 2010-02-05 [InstanceEdit:504071] D'Eustachio, P, 2010-02-07 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9975916] D'Eustachio, Peter, 2025-12-04
name	dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] phosphorylation of dUMP or TMP to dUDP or TDP dUMP + ATP => dUDP + ADP dTMP + ATP => dTDP + ADP
output	[DefinedSet:499999] dUDP, TDP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:73596] dCMP + H2O => dUMP + NH4+ [Homo sapiens] [Reaction:73598] (2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) [Homo sapiens] [Reaction:75125] (d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) [Homo sapiens] [Reaction:73605] conversion of dUMP to dTMP [Homo sapiens] [Reaction:73596] dCMP + H2O => dUMP + NH4+ [Homo sapiens] [Reaction:73666] hydrolysis of 2'-deoxyuridine 5'-triphosphate to form 2'-deoxyuridine 5'-phosphate [Homo sapiens] [Reaction:73632] phosphorylation of 2'-Deoxythymidine to dTMP [Homo sapiens]
releaseDate	2004-07-06
reverseReaction	[Reaction:75126] dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] [Homo sapiens] [Reaction:73635] dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] [Homo sapiens]
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:362042] R-HSA-73635.6
summation	[Summation:178320] Cytosolic deoxythymidylate kinase (DTYMK) catalyzes the reve...
(hasEvent)	[Pathway:499943] Interconversion of nucleotide di- and triphosphates [Homo sapiens]
(precedingEvent)	[Reaction:482619] (d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) [Homo sapiens]
(replacementInstances)	[_Deleted:500000] Deletion of instance: 73631 [_Deleted:500005] Deletion of instance: 110104
(reverseReaction)	[Reaction:75126] dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790956] Update Tracker - [Reaction:73635] dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] - v32:[add_removeInput, add_removeOutput, modifyText]
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