Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person phosphorylation of 2'-Deoxythymidine to dTMP

Class:IdReaction:73632
_displayNamephosphorylation of 2'-Deoxythymidine to dTMP
_doReleaseTRUE
_timestamp2025-12-16 18:01:45
catalystActivity[CatalystActivity:73502] nucleoside kinase activity of TK1 tetramer [cytosol]
catalystActivityReference[CatalystActivityReference:9643329] nucleoside kinase activity of TK1 tetramer [cytosol] Structure of a type II thymidine kinase with bound dTTP
compartment[Compartment:70101] cytosol
created[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
crossReference[DatabaseIdentifier:9976252] RHEA:19130
input[SimpleEntity:83928] Thy-dRib [cytosol]
[SimpleEntity:113592] ATP [cytosol]
internalReviewed[InstanceEdit:9977060] D'Eustachio, Peter, 2025-12-16
literatureReference[LiteratureReference:500810] Structure of a type II thymidine kinase with bound dTTP
[LiteratureReference:109764] Human deoxythymidine kinase. I. Purification and general properties of the cytoplasmic and mitochondrial isozymes derived from blast cells of acute myelocytic leukemia
[LiteratureReference:109747] Diverging substrate specificity of pure human thymidine kinases 1 and 2 against antiviral dideoxynucleosides
[LiteratureReference:109771] Reversible ATP-dependent transition between two forms of human cytosolic thymidine kinase with different enzymatic properties
[LiteratureReference:109774] Regulation of human thymidine kinase during the cell cycle
[LiteratureReference:109772] Human cytosolic thymidine kinase. Purification and physical characterization of the enzyme from HeLa cells
modified[InstanceEdit:74362] D'Eustachio, P, 2003-07-18 15:39:00
[InstanceEdit:74479] D'Eustachio, P, 2003-07-22 16:21:00
[InstanceEdit:109769] D'Eustachio, P, 2004-01-20 17:05:00
[InstanceEdit:109918] D'Eustachio, P, 2004-01-22 15:13:00
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:500461] D'Eustachio, P, 2010-02-03
[InstanceEdit:500809] D'Eustachio, P, 2010-02-05
[InstanceEdit:504063] D'Eustachio, P, 2010-02-05
[InstanceEdit:504071] D'Eustachio, P, 2010-02-07
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9976255] D'Eustachio, Peter, 2025-12-09
[InstanceEdit:9977061] D'Eustachio, Peter, 2025-12-16
[InstanceEdit:9977063] D'Eustachio, Peter, 2025-12-16
namephosphorylation of 2'-Deoxythymidine to dTMP
thymidine + ATP => dTMP + ADP + H(+)
thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1]
output[SimpleEntity:109366] TMP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:70106] H+ [cytosol]
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2004-07-06
reviewed[InstanceEdit:9977064] D'Eustachio, Peter, 2025-12-16
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:360194] R-HSA-73632.5
structureModified[InstanceEdit:9976255] D'Eustachio, Peter, 2025-12-09
summation[Summation:179210] Cytosolic thymidine kinase 1 (TK1) catalyzes the reaction of...
(hasEvent)[Pathway:73614] Pyrimidine salvage [Homo sapiens]
(precedingEvent)[Reaction:73635] dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] [Homo sapiens]
(replacementInstances)[_Deleted:500818] Deletion of instance: 109770
(updatedInstance)[_UpdateTracker:9791194] Update Tracker - [Reaction:73632] thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1] - v32:[addLiteratureReference, modifyText]
[_UpdateTracker:9984657] Update Tracker - [Reaction:73632] phosphorylation of 2'-Deoxythymidine to dTMP - v96:[removeOutput]
[Change default viewing format]
No pathways have been reviewed or authored by phosphorylation of 2'-Deoxythymidine to dTMP (73632)
Follow Reactome