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Details on Person conversion of 3-Ureidoiosbutyrate to 3-Aminoisobutyrate

Class:IdReaction:73620
_displayNameconversion of 3-Ureidoiosbutyrate to 3-Aminoisobutyrate
_doReleaseTRUE
_timestamp2025-12-11 22:36:13
authored[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
catalystActivity[CatalystActivity:73466] beta-ureidopropionase activity of UPB1:Zn2+ [cytosol]
catalystActivityReference[CatalystActivityReference:9643299] beta-ureidopropionase activity of UPB1:Zn2+ [cytosol] beta-Ureidopropionase deficiency: an inborn error of pyrimidine degradation associated with neurological abnormalities
compartment[Compartment:70101] cytosol
created[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
crossReference[DatabaseIdentifier:9976528] RHEA:37340
edited[InstanceEdit:74362] D'Eustachio, P, 2003-07-18 15:39:00
input[SimpleEntity:73617] UIBA [cytosol]
[SimpleEntity:29356] H2O [cytosol]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:70106] H+ [cytosol]
literatureReference[LiteratureReference:909759] Purification, properties, and sequencing of aminoisobutyrate aminotransferases from rat liver
[LiteratureReference:200178] beta-Ureidopropionase deficiency: an inborn error of pyrimidine degradation associated with neurological abnormalities
modified[InstanceEdit:73832] Jassal, B, 2003-07-03 08:48:35
[InstanceEdit:74362] D'Eustachio, P, 2003-07-18 15:39:00
[InstanceEdit:75119] D'Eustachio, P, 2003-08-25 12:00:00
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:200252] D'Eustachio, P, 2007-07-16 20:10:20
[InstanceEdit:504063] D'Eustachio, P, 2010-02-05
[InstanceEdit:504071] D'Eustachio, P, 2010-02-07
[InstanceEdit:688142] Jassal, B, 2010-05-07
[InstanceEdit:692410] D'Eustachio, P, 2010-05-07
[InstanceEdit:909782] D'Eustachio, P, 2010-07-07
[InstanceEdit:1080820] D'Eustachio, P, 2010-11-27
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9737738] D'Eustachio, Peter, 2021-07-21
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9976516] D'Eustachio, Peter, 2025-12-11
nameconversion of 3-Ureidoiosbutyrate to 3-Aminoisobutyrate
3-(carbamoylamino)-2-methylpropanoate + H2O + 2 H(+) => (R)-3-amino-2-methylpropanoate + NH4(+) + CO2
output[SimpleEntity:113528] CO2 [cytosol]
[SimpleEntity:31633] NH4+ [cytosol]
[SimpleEntity:73619] 3AIB [cytosol]
precedingEvent
releaseDate2004-07-06
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:359359] R-HSA-73620.6
summation[Summation:178508] Cytosolic UPB1 (beta-ureidopropionase) catalyzes the reactio...
(hasEvent)[Pathway:73621] Pyrimidine catabolism [Homo sapiens]
(precedingEvent)[BlackBoxEvent:909755] Mitochondrial uptake of (R)-3-aminoisobutyric acid [Homo sapiens]
(updatedInstance)[_UpdateTracker:9775617] Update Tracker - [Reaction:73620] beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 - v78:[addInput]
[_UpdateTracker:9790275] Update Tracker - [Reaction:73620] beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 - v34:[addLiteratureReference, modifyText]
[_UpdateTracker:9790395] Update Tracker - [Reaction:73620] beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 - v33:[add_removeOutput]
[_UpdateTracker:9792276] Update Tracker - [Reaction:73620] beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2 - v22:[addLiteratureReference]
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