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Details on Person reduction of thymine to form 5,6-Dihydrothymine

Class:Id	Reaction:73616
_displayName	reduction of thymine to form 5,6-Dihydrothymine
_doRelease	TRUE
_timestamp	2025-12-11 22:36:18
catalystActivity	[CatalystActivity:73530] dihydropyrimidine dehydrogenase (NADP+) activity of DPYD dimer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
crossReference	[DatabaseIdentifier:9976497] RHEA:58286
input	[SimpleEntity:83960] Thy [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:70106] H+ [cytosol]
literatureReference	[LiteratureReference:200230] cDNA cloning and chromosome mapping of human dihydropyrimidine dehydrogenase, an enzyme associated with 5-fluorouracil toxicity and congenital thymine uraciluria
modified	[InstanceEdit:73832] Jassal, B, 2003-07-03 08:48:35 [InstanceEdit:74362] D'Eustachio, P, 2003-07-18 15:39:00 [InstanceEdit:75119] D'Eustachio, P, 2003-08-25 12:00:00 [InstanceEdit:113791] Schmidt, EE, 2004-06-22 11:07:51 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:170422] Jassal, B, 2006-01-06 09:35:29 [InstanceEdit:200252] D'Eustachio, P, 2007-07-16 20:10:20 [InstanceEdit:500461] D'Eustachio, P, 2010-02-03 [InstanceEdit:504063] D'Eustachio, P, 2010-02-05 [InstanceEdit:504071] D'Eustachio, P, 2010-02-07 [InstanceEdit:662891] D'Eustachio, P, 2010-05-03 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9976516] D'Eustachio, Peter, 2025-12-11
name	reduction of thymine to form 5,6-Dihydrothymine thymine + NADPH + H(+) => 5,6-dihydrothymine + NADP(+)
output	[SimpleEntity:73541] 5,6-Dihydrothymine [cytosol] [SimpleEntity:29366] NADP+ [cytosol]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359875] R-HSA-73616.4
summation	[Summation:179234] Cytosolic dihydropyrimidine dehydrogenase catalyzes the reac...
(hasEvent)	[Pathway:73621] Pyrimidine catabolism [Homo sapiens]
(precedingEvent)	[Reaction:73618] conversion of 5,6-Dihydrothymine to 3-Ureidoisobutyrate [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790654] Update Tracker - [Reaction:73616] thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ - v33:[add_removeCatalystActivity] [_UpdateTracker:9792237] Update Tracker - [Reaction:73616] thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ - v22:[addLiteratureReference, modifyText]
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